| Tbio | Extracellular superoxide dismutase [Cu-Zn] |
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hypertension | 396 | 3.503 | 1.8 |
| Chemical and Drug Induced Liver Injury | 195 | 0.0 | 0.0 |
| Dermatitis, Contact | 71 | 0.0 | 0.0 |
| Disease Progression | 136 | 0.0 | 0.0 |
| Heart failure | 162 | 0.0 | 0.0 |
| Lymphoma, Large B-Cell, Diffuse | 34 | 0.0 | 0.0 |
| Necrosis | 53 | 0.0 | 0.0 |
| Pulmonary Disease, Chronic Obstructive | 31 | 0.0 | 0.0 |
| Pulmonary Fibrosis | 106 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Chronic Obstructive Airway Disease | 37 |
| Contact Dermatitis | 81 |
| Diffuse large B-cell lymphoma | 39 |
| Hypertensive disease | 292 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 5.6e-12 |
| lung carcinoma | 2843 | 5.9e-09 |
| psoriasis | 6694 | 1.8e-07 |
| breast carcinoma | 1638 | 2.0e-05 |
| lung cancer | 4740 | 5.5e-05 |
| ductal carcinoma in situ | 1745 | 3.0e-04 |
| lung adenocarcinoma | 2716 | 2.5e-03 |
| fibroadenoma | 559 | 2.9e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 4.5e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.4e-02 |
| invasive ductal carcinoma | 2951 | 2.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Mental Depression | 333 | 0.0 | 0.9 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Lung disease | 142 | 3.791 | 1.9 |
| Atherosclerosis | 291 | 3.354 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| breast carcinoma | -2.600 | 2.0e-05 |
| ductal carcinoma in situ | -1.900 | 3.0e-04 |
| fibroadenoma | -2.400 | 2.9e-03 |
| intraductal papillary-mucinous adenoma (... | -1.100 | 4.5e-03 |
| intraductal papillary-mucinous neoplasm ... | -1.100 | 1.4e-02 |
| invasive ductal carcinoma | -1.101 | 2.3e-02 |
| lung adenocarcinoma | -1.100 | 2.5e-03 |
| lung cancer | -2.200 | 5.5e-05 |
| lung carcinoma | 1.600 | 5.9e-09 |
| non-small cell lung cancer | -1.318 | 5.6e-12 |
| psoriasis | -1.400 | 1.8e-07 |
