| Tbio | Extracellular superoxide dismutase [Cu-Zn] |
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2798 | 5.6150733885442E-12 |
| lung carcinoma | 2844 | 5.93748620760933E-9 |
| psoriasis | 6685 | 1.75991481603598E-7 |
| breast carcinoma | 1614 | 2.03207940916804E-5 |
| lung cancer | 4473 | 5.48917334029169E-5 |
| ductal carcinoma in situ | 1745 | 3.0381637652718E-4 |
| invasive ductal carcinoma | 2950 | 0.00144111326693324 |
| lung adenocarcinoma | 2714 | 0.00250456227212925 |
| fibroadenoma | 557 | 0.00286264181147711 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 0.00445205663705126 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.0136232565785734 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Lung disease | 136 | 3.73 | 1.9 |
| Hypertension | 293 | 3.513 | 1.8 |
| Atherosclerosis | 275 | 3.387 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| psoriasis | -1.400 | 0.000 |
| non-small cell lung cancer | -1.318 | 0.000 |
| intraductal papillary-mucinous adenoma (... | -1.100 | 0.004 |
| intraductal papillary-mucinous neoplasm ... | -1.100 | 0.014 |
| lung cancer | -2.200 | 0.000 |
| breast carcinoma | -2.600 | 0.000 |
| fibroadenoma | -2.400 | 0.003 |
| lung adenocarcinoma | -1.100 | 0.003 |
| invasive ductal carcinoma | -2.500 | 0.001 |
| lung carcinoma | 1.600 | 0.000 |
| ductal carcinoma in situ | -1.900 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG |
| Pig | OMA EggNOG |
| Opossum | OMA EggNOG Inparanoid |
| Chicken | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 26006040 | Extracellular superoxide dismutase ameliorates streptozotocin-induced rat diabetic nephropathy via inhibiting the ROS/ERK1/2 signaling. |
| 25894370 | ECSOD Ala40Thr polymorphism, a significant association was observed between this polymorphism and HCC risk in non-hepatitis B virus (HBV) carriers but not in HBV carriers |
| 25855220 | The T-allele of rs2284659 in the promoter of SOD3 was associated with better cardiovascular outcomes in diabetic patients. |
| 25751262 | SOD3 regulates the expression of multiple components of small G protein GTPase signal pathways. |
| 25749103 | Expression of extracellular superoxide dismutase (EC-SOD) and expression of the prooxidant gene NADPH oxidase 4 was decreased significantly by trichostatin A. |
| 25634994 | These results support the hypothesis that loss of extracellular SOD contributes to the invasive phenotype of pancreatic ductal adenocarcinoma |
| 25496033 | FXR may regulate SOD3 expression to suppress reactive oxygen species production, resulting in decreasing JNK activity. |
| 25358638 | Sod3 is a critical mediator of VEGF-C-induced breast cancer metastasis. |
| 25332062 | The combination of serum S100A9, SOD3, and MMP9 levels could achieve 92.5% sensitivity and 95% specificity to discriminate between pulmonary tuberculosis and healthy controls. |
| 25130429 | The treatment with E2 suppressed, whereas VC and Res prevented E2-mediated decrease in the expression levels of SOD3, NQO1, Nrf2 mRNA, and protein in MCF-10A cells |
| More... |
| PMID | Year | Title |
|---|---|---|
| 26006040 | 2015 | Extracellular superoxide dismutase ameliorates streptozotocin-induced rat diabetic nephropathy via inhibiting the ROS/ERK1/2 signaling. |
| 25894370 | 2015 | Genetic polymorphisms in antioxidant enzyme genes and susceptibility to hepatocellular carcinoma in Chinese population: a case-control study. |
| 25855220 | 2015 | Plasma extracellular superoxide dismutase concentration, allelic variations in the SOD3 gene and risk of myocardial infarction and all-cause mortality in people with type 1 and type 2 diabetes. |
| 25751262 | 2015 | Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI. |
| 25749103 | 2015 | Regulation of Oxidative Stress in Pulmonary Artery Endothelium. Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors. |
| 25644107 | 2015 | Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease. |
| 25634994 | 2015 | Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma. |
| 25496033 | 2015 | Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25358638 | 2014 | Vascular endothelial growth factor C promotes breast cancer progression via a novel antioxidant mechanism that involves regulation of superoxide dismutase 3. |
| More... |
