GSTA1
Glutathione S-transferase A1
Protein Summary
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
- ENST00000334575
- ENSP00000335620
- ENSG00000243955
- GST2
- GTH1
- GSTA1-1
- GST-epsilon
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 0.99 | ||
phenotype | 0.98 | ||
disease | 0.96 | ||
biological term | 0.85 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 355.16 (req: < 5)
Gene RIFs: 132 (req: <= 3)
Antibodies: 453 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 355.16 (req: >= 5)
Gene RIFs: 132 (req: > 3)
Antibodies: 453 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 11
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0