Property Summary

NCBI Gene PubMed Count 189
PubMed Score 235.64
PubTator Score 287.28

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
psoriasis 6685 7.79613314422572E-12
Breast cancer 3099 4.03424449032993E-9
nasopharyngeal carcinoma 1056 9.60649840080232E-7
cystic fibrosis 1670 1.42092349710304E-5
pancreatic cancer 2300 7.07081208755403E-4
non-small cell lung cancer 2798 0.00123776618941736
diabetes mellitus 1663 0.00134175440399127
lung carcinoma 2844 0.00297703128772326
ulcerative colitis 2087 0.00352496000892779
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00483244919317417
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00489216830984613
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0109998673173185
head and neck cancer and chronic obstructive pulmonary disease 237 0.012313511818601
primary pancreatic ductal adenocarcinoma 1271 0.0141133276774007
aldosterone-producing adenoma 664 0.019519133710606
adrenocortical carcinoma 1427 0.0231818672405485
nephrosclerosis 329 0.0382355270101558
colon cancer 1475 0.0488778421287004
Disease Target Count Z-score Confidence
Cancer 2346 3.785 1.9



Accession P08263 Q14750 Q5GHF8 Q5SZC1
Symbols GST2



1LBK   1GSD   1GSE   1GSF   1GUH   1K3L   1K3O   1K3Y   1PKW   1PKZ   1PL1   1PL2   1USB   1XWG   1YDK   2R3X   2R6K   3I69   3I6A   3IK9   3KTL   3L0H   3Q74   3U6V   3ZFB   3ZFL   4HJ2   5LCZ  

Gene RIF (173)

26552558 The frequency of GSTA1, GSTM1 and GSTP1 genotypes was not significantly different between progressive myoclonus epilepsy patients and controls
26419450 this is the first population pharmacokinetic study to suggest that GSTA1 polymorphisms in adults are associated with busulfan pharmacokinetics
26321410 GSTA1 polymorphism is associated with different pregnancy-related conditions
26222310 Patients with a GSTA1*A heterozygous variant had a lower exposure to 4-hydroxycyclophosphamide (4OHCTX) during cyclophosphamide treatment of lupus nephritis compared to wild-type patients.
25867434 Data show that the distribution of the glutathione S-transferases alleles GSTA1*A/*B and GSTP1*A, *B, and *C in the Polish population correspond to the results of studies in Caucasians.
25778330 Review/Meta-analysis: suggest that GSTA1 BB genotype was a risk factor for colorectal cancer, especially in Caucasian populations.
25730183 the differences of PK in BU among different ethnic groups existed because of the different distribution frequencies of GST gene polymorphism in Chinese patients and Caucasian patients.
25565670 GST genotyping before hematopoietic stem cell transplantation may allow better prediction of busulfan pharmacokinetics and drug toxicity, and thereby improve outcome after busulfan and cyclophosphamide conditioning
25374180 Our data indicated that GSTA1 expression may be a target molecule in early diagnosis and treatment of lung cancer
25251951 The distribution of genotype frequencies of the polymorphism GSTA1 was statistically different between cases and controls, and the presence of genotypes A / B and B / B suggests a protective role against the risk of PCa compared to genotype A / A.

AA Sequence

KSLEEARKIFRF                                                              211 - 222

Text Mined References (191)

PMID Year Title
26552558 2015 GSTA1, GSTM1, GSTP1 and GSTT1 polymorphisms in progressive myoclonus epilepsy: A Serbian case-control study.
26419450 2015 Population pharmacokinetics and pharmacodynamics of busulfan with GSTA1 polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation.
26321410 2015 GSTA1 gene variation associated with gestational hypertension and its involvement in pregnancy-related pathogenic conditions.
26222310 2015 The GSTA1 polymorphism and cyclophosphamide therapy outcomes in lupus nephritis patients.
25867434 2015 Polymorphisms and allele frequencies of glutathione S-transferases A1 and P1 genes in the Polish population.
25778330 Polymorphisms of GSTA1 contribute to elevated cancer risk: evidence from 15 studies.
25730183 2015 Once-daily i.v. BU-based conditioning regimen before allogeneic hematopoietic SCT: a study of influence of GST gene polymorphisms on BU pharmacokinetics and clinical outcomes in Chinese patients.
25565670 2015 Glutathione Transferase Gene Variants Influence Busulfan Pharmacokinetics and Outcome After Myeloablative Conditioning.
25374180 2014 Expression and function of GSTA1 in lung cancer cells.
25251951 Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population.