Property Summary

NCBI Gene PubMed Count 17
PubMed Score 1.49
PubTator Score 18.65

Knowledge Summary


No data available


  Disease (2)

Disease Target Count
Hypertensive disease 193
Disease Target Count Z-score Confidence
Exocrine pancreatic insufficiency 21 3.495 1.7


Gene RIF (3)

20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
16247445 analysis of regulation of hELA2 gene expression suggests transcriptional effects of AML1-ETO are more complex than simple DNA binding and repression via recruitment of corepressors

AA Sequence


Text Mined References (18)

PMID Year Title
20932654 2010 Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20179351 2010 Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16327289 2006 Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans.
16247445 2006 ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11729383 2001 Identification of disease-specific genes in chronic pancreatitis using DNA array technology.
10620133 2000 Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism.
3646943 1987 Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.
3427074 1987 Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.
2834346 1987 Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2.
2307232 1990 Further studies on the human pancreatic binary complexes involving procarboxypeptidase A.