ABCB1
Multidrug resistance protein 1
Protein Summary
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternativ ...more
- ENST00000265724
- ENSP00000265724
- ENSG00000085563
- ENST00000543898
- ENSP00000444095
- ENST00000622132
- ENSP00000478255
- MDR1
- PGY1
- CLCS
- MDR1
- P-GP
- PGY1
- ABC20
- CD243
- GP170
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
drug | 1 | ||
molecular function | 0.99 | ||
co-expressed gene | 0.98 | ||
gene perturbation | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6875.82 (req: < 5)
Gene RIFs: 2070 (req: <= 3)
Antibodies: 1260 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6875.82 (req: >= 5)
Gene RIFs: 2070 (req: > 3)
Antibodies: 1260 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 919
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 20