Tclin CHRM2 Muscarinic acetylcholine receptor M2

Protein Summary

Description

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P08172
• Q4VBK6
• Q9P1X9

Gene Name

• CHRM2

Ensembl ID

• ENST00000320658
• ENSP00000319984
• ENSG00000181072
• ENST00000401861
• ENSP00000384401
• ENST00000445907
• ENSP00000399745
• ENST00000453373
• ENSP00000415386

Symbol

• HM2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
ligand (chemical)	1
chemical	0.84
biological process	0.79
disease	0.72

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Muscarinic Acetylcholine Receptor M2

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Acetylcholine Receptor (Muscarinic) / Muscarinic Acetylcholine Receptor M2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1232.72   (req: < 5)

Gene RIFs: 95   (req: <= 3)

Antibodies: 526   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1232.72   (req: >= 5)

Gene RIFs: 95   (req: > 3)

Antibodies: 526   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 923

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 46