Tclin NGFR Tumor necrosis factor receptor superfamily member 16

Protein Summary

Description

Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P08138
• B2R961
• B4E096

Gene Name

• NGFR

Ensembl ID

• ENST00000172229
• ENSP00000172229
• ENSG00000064300
• ENST00000504201
• ENSP00000421731

Symbol

• TNFRSF16
• CD271
• p75NTR
• TNFRSF16
• p75(NTR)
• Gp80-LNGFR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
PubMedID	0.87
ligand (protein)	0.85
protein complex	0.74
biological term	0.71

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Tumor Necrosis Factor Receptor / Tumor Necrosis Factor Receptor Superfamily Member 16

DTO Classes

Protein / Receptor / Cytokine Receptor / Tumor Necrosis Factor Receptor / Tumor Necrosis Factor Receptor Superfamily Member 16

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1528.28   (req: < 5)

Gene RIFs: 264   (req: <= 3)

Antibodies: 1398   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1528.28   (req: >= 5)

Gene RIFs: 264   (req: > 3)

Antibodies: 1398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1