RHOC
Rho-related GTP-binding protein RhoC
Protein Summary
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided b ...more
- ENST00000285735
- ENSP00000285735
- ENSG00000155366
- ENST00000339083
- ENSP00000345236
- ENST00000369632
- ENSP00000358646
- ENST00000369633
- ENSP00000358647
- ENST00000369637
- ENSP00000358651
- ENST00000369638
- ENSP00000358652
- ENST00000369642
- ENSP00000358656
- ARH9
- ARHC
- H9
- ARH9
- ARHC
- RHOH9
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.88 | ||
PubMedID | 0.87 | ||
transcription factor perturbation | 0.84 | ||
disease perturbation | 0.83 | ||
molecular function | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 495.43 (req: < 5)
Gene RIFs: 133 (req: <= 3)
Antibodies: 318 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 495.43 (req: >= 5)
Gene RIFs: 133 (req: > 3)
Antibodies: 318 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0