You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
IGF1R
Insulin-like growth factor 1 receptor

Protein Summary
Description
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downs ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268035
  • ENSP00000268035
  • ENSG00000140443
  • ENST00000650285
  • ENSP00000497069

Symbol
  • IGFR
  • CD221
  • IGFIR
  • JTK13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
protein domain
1
biological term
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3436.91   (req: < 5)
Gene RIFs: 1018   (req: <= 3)
Antibodies: 2145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3436.91   (req: >= 5)
Gene RIFs: 1018   (req: > 3)
Antibodies: 2145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 862
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4