Property Summary

NCBI Gene PubMed Count 267
PubMed Score 4405.48
PubTator Score 2020.79

Knowledge Summary


No data available


  Disease Sources (5)

Disease Target Count
Chronic hepatitis C 12
Disease Target Count P-value
lung carcinoma 2844 2.92637674315677E-14
juvenile dermatomyositis 1189 2.21533847267401E-9
ovarian cancer 8492 1.68365049971616E-6
acute quadriplegic myopathy 1157 2.54210226411099E-6
malignant mesothelioma 3163 2.90522531988696E-6
inflammatory breast cancer 404 3.14445435465511E-6
Duchenne muscular dystrophy 602 3.23316518581053E-6
cystic fibrosis 1670 4.3227004148348E-6
invasive ductal carcinoma 2950 1.90972701544226E-5
medulloblastoma 1524 2.85499397443621E-5
medulloblastoma, large-cell 6234 3.12951053980987E-5
osteosarcoma 7933 1.92483711316876E-4
cutaneous lupus erythematosus 1056 2.73774432186629E-4
lung cancer 4473 0.00108386743261872
breast carcinoma 1614 0.00234602142564996
primary pancreatic ductal adenocarcinoma 1271 0.00263961803846597
pancreatic cancer 2300 0.00295129142044178
atypical teratoid / rhabdoid tumor 4369 0.00303851004630159
astrocytoma 1493 0.010893052368329
subependymal giant cell astrocytoma 2287 0.0172741396681642
gastric carcinoma 832 0.02734759662822
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0298106540902042
Disease Target Count Z-score Confidence
Parkinson's disease 364 0.0 1.0



Accession P07858 B3KQR5 B3KRR5 Q503A6 Q96D87
Symbols APPS


PANTHER Protein Class (3)


3K9M   1CSB   1GMY   1HUC   1PBH   2IPP   2PBH   3AI8   3CBJ   3CBK   3PBH  

  Ortholog (12)

Gene RIF (191)

27031837 Cathepsin B knockdown in oral cancer cells reduces cell migration.
26904684 High activity of cathepsin B and increased level of cystatin C are typical for women in late pregnancy. Those levels significantly decrease after delivery which can be associated with potential role of those markers in placental separation
26896959 CTSB might be involved in the development and progression of hepatocellular carcinoma.
26081835 shedding of surface proteins by extracellular cathepsins impacts intracellular signaling as demonstrated for regulation of Ras GTPase activity.
25991043 The serum level of cathepsin L decreased with age, while cathepsin B remained no significant difference between young and aged individuals
25959927 the authors applied the technique of nanoelectrode arrays to try to detect and compare cathepsin B activities in normal and breast cancer cells. It was found that protease activity correlated positively with the degree of malignancy cancer cells.
25883214 High cathepsin is associated with drug resistance in neuroblastoma.
25802234 SCD5 impairs SPARC and cathepsin B secretion in human melanoma cells and intracellular pH acidification.
25633482 Cathepsins B and L activity correlates with the efficiency of reovirus-mediated tumor cell killing.
25577554 enhanced activity and expression of cathepsin B contributes to an increased remodelling of extracellular matrix that favours leiomyoma growth

AA Sequence


Text Mined References (270)

PMID Year Title
27031837 2016 Cathepsin B Expression and the Correlation with Clinical Aspects of Oral Squamous Cell Carcinoma.
26904684 2016 Activity of Proteolytic Enzymes and Level of Cystatin C in the Peripartum Period.
26896959 2016 Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients.
26081835 2015 Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells.
25991043 Differential levels of cathepsin B and L in serum between young and aged healthy people and their association with matrix metalloproteinase 2.
25959927 2015 Quantitative electrochemical detection of cathepsin B activity in breast cancer cell lysates using carbon nanofiber nanoelectrode arrays toward identification of cancer formation.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25883214 2015 Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin.
25802234 2015 SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B.
25633482 2015 Activity levels of cathepsins B and L in tumor cells are a biomarker for efficacy of reovirus-mediated tumor cell killing.