Property Summary

NCBI Gene PubMed Count 115
Grant Count 31
R01 Count 14
Funding $3,205,112.95
PubMed Score 199.62
PubTator Score 159.68

Knowledge Summary


No data available


Gene RIF (69)

26787927 evidence, which suggests that Profilin increases tumour suppressor activity by regulating NF-kappaB.
26572741 Actin independent mechanisms contribute to the pathogenicity of PFN1 T109M and possibly other PFN1 mutations.
26499959 expression of the ALS-associated actin-binding deficient mutant of PFN1 (PFN1(C71G)) results in increased dendritic arborisation and spine formation, and cytoplasmic inclusions in cultured mouse hippocampal neurons
26227615 Profilin-1 folding process occurs in the absence of thermodynamically stable partially folded states.
26226631 Mutations of profilin-1, associated with familial amyotrophic lateral sclerosis, increase the tendency of profilin-1 to aggregate and that such aggregation behavior is largely determined by the mutation-induced structural changes occurring in the folded state of the protein.
26056300 findings suggest that a destabilized form of PFN1 underlies PFN1-mediated ALS pathogenesis
25741138 Suggest that PFN1 plays a critical role in gastric carcinoma progression, and these effects are likely mediated through the integrin beta1/FAK pathway.
25704627 Higher messenger RNA expression of Profilin-1 is associated with significantly lower survival
25613364 Profilin1 acts as a molecular regulator of the levels of PI(3,4)P2 and Tks5 recruitment in invadopodia to control the invasion efficiency of invadopodia.
25499087 PFN1 is a rare cause of ALS.

AA Sequence


Text Mined References (125)

PMID Year Title
26787927 2016 Profilin-PTEN interaction suppresses NF-?B activation via inhibition of IKK phosphorylation.
26572741 2015 Profilin 1 with the amyotrophic lateral sclerosis associated mutation T109M displays unaltered actin binding and does not affect the actin cytoskeleton.
26499959 2015 Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons.
26227615 2015 The Folding process of Human Profilin-1, a novel protein associated with familial amyotrophic lateral sclerosis.
26226631 2015 Mutations of Profilin-1 Associated with Amyotrophic Lateral Sclerosis Promote Aggregation Due to Structural Changes of Its Native State.
26056300 2015 Structural basis for mutation-induced destabilization of profilin 1 in ALS.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25741138 2015 Silencing profilin-1 inhibits gastric cancer progression via integrin ?1/focal adhesion kinase pathway modulation.
25704627 2015 Profilin-1 expression is associated with high grade and stage and decreased disease-free survival in renal cell carcinoma.
25613364 2015 Profilin1 regulates invadopodium maturation in human breast cancer cells.