Protein Summary
Important for the overall degradation of proteins in lysosomes. The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
- ENST00000340342
- ENSP00000365061
- ENSG00000135047
- ENST00000343150
- ENSP00000345344
- CTSL1
- MEP
- CATL
- CTSL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease | 0.99 | ||
cellular component | 0.93 | ||
biological term | 0.92 | ||
kinase perturbation | 0.91 | ||
transcription factor perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2018.6 (req: < 5)
Gene RIFs: 174 (req: <= 3)
Antibodies: 528 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2018.6 (req: >= 5)
Gene RIFs: 174 (req: > 3)
Antibodies: 528 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1122
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2