Property Summary

NCBI Gene PubMed Count 195
PubMed Score 1058.33
PubTator Score 431.62

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
breast carcinoma 1614 2.86116572750557E-26
lung carcinoma 2844 1.41114541665405E-20
non-small cell lung cancer 2798 2.53894122613926E-12
lung adenocarcinoma 2714 4.96061922293101E-10
malignant mesothelioma 3163 1.19334250610713E-9
ovarian cancer 8492 2.34113281661523E-9
cystic fibrosis 1670 1.64897670755681E-7
Duchenne muscular dystrophy 602 2.41976153932279E-6
lung cancer 4473 2.47423979535168E-6
intraductal papillary-mucinous carcinoma (IPMC) 2988 6.54387370784986E-6
intraductal papillary-mucinous adenoma (IPMA) 2956 2.66978284549132E-5
pituitary cancer 1972 3.4471588917653E-5
invasive ductal carcinoma 2950 6.99525596864288E-5
primary pancreatic ductal adenocarcinoma 1271 7.51573545669662E-5
psoriasis 6685 9.03619440269923E-5
Atopic dermatitis 944 1.02942850685632E-4
sonic hedgehog group medulloblastoma 1482 1.19060353794786E-4
ulcerative colitis 2087 1.37815694167653E-4
limb girdle muscular dystrophy 2A 156 3.38913644809445E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 3.73752107236325E-4
pancreatic cancer 2300 5.00950759158881E-4
osteosarcoma 7933 8.29945731602892E-4
medulloblastoma, large-cell 6234 0.00129515761852676
adrenocortical carcinoma 1427 0.00231593481267999
Down syndrome 548 0.00293587588698062
pilocytic astrocytoma 3086 0.00362440531094405
colon cancer 1475 0.00541497468405086
ductal carcinoma in situ 1745 0.00971421923576728
interstitial lung disease 292 0.010842629972871
Pick disease 1893 0.0130877419642923
Polycystic Ovary Syndrome 335 0.0149904823866089
adrenocortical adenoma 134 0.0169820169195386
non primary Sjogren syndrome sicca 840 0.0191241367898915
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.0276512540551066
cutaneous lupus erythematosus 1056 0.0337998668988603
glioblastoma 5572 0.0338909015074737
aldosterone-producing adenoma 664 0.0344320185468702
facioscapulohumeral dystrophy 286 0.0413548076325122
ependymoma 2514 0.0444052357362781



Accession P07585 Q9P0Z0 Q9P0Z1 Q9Y5N8 Q9Y5N9
Symbols CSCD



  Ortholog (12)

Gene RIF (145)

26828927 Decorin plays a key role in the maintenance of the order in the normal corneal extracellular matrix.
26697491 An emerging concept that multiple proteases, especially those produced by inflammatory cells, are capable of cleaving DCN suggests that native DCN could be inactivated in a number of pathological inflammatory conditions
26554635 increased blood DCN levels could be a candidate biomarker for PE.
26400336 Compared with bone graft and marrow cavity contents, sticking scars had the highest expression of BMP-2 while bone grafts had the highest expression of DCN.
26001829 decorin expression and immunoreactivity in normal and malignant human colorectal tissue
25661523 Data show that decorin is not only associated with angiogenesis, but it plays a causal role in this process. Also, depending on the molecular microenvironment where angiogenesis is induced, decorin can either promote or inhibit angiogenesis. [review]
25656619 Defective Proteolytic Processing of Fibrillar Procollagens and Prodecorin Due to Biallelic BMP1 Mutations Results in a Severe, Progressive Form of Osteogenesis Imperfecta.
25550184 DCN is a key regulator for chemoresistant mechanisms.
25524578 decorin plays crucial roles in non-small-cell lung cancer against carcinogenesis and progression.
25407518 findings indicate that decorin may indirectly act as an antagonist to MM cell survival and that the interplay between MM and decorin may be an important target to explore in manipulating the tumor niche to inhibit tumorigenesis

AA Sequence

SAIQLGNYK                                                                 351 - 359

Text Mined References (196)

PMID Year Title
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
26828927 2016 Role of Decorin Core Protein in Collagen Organisation in Congenital Stromal Corneal Dystrophy (CSCD).
26697491 2015 Decorin: A Growth Factor Antagonist for Tumor Growth Inhibition.
26554635 2016 Restraint of Trophoblast Invasion of the Uterus by Decorin: Role in Pre-eclampsia.
26400336 2015 Bone morphogenetic protein 2 and decorin expression in old fracture fragments and surrounding tissues.
26001829 2015 Decorin in Human Colon Cancer: Localization In Vivo and Effect on Cancer Cell Behavior In Vitro.
25661523 2015 Pivotal role for decorin in angiogenesis.
25656619 2015 Defective Proteolytic Processing of Fibrillar Procollagens and Prodecorin Due to Biallelic BMP1 Mutations Results in a Severe, Progressive Form of Osteogenesis Imperfecta.
25550184 2015 Decorin in human oral cancer: a promising predictive biomarker of S-1 neoadjuvant chemosensitivity.
25524578 2015 Decorin is responsible for progression of non-small-cell lung cancer by promoting cell proliferation and metastasis.