Tclin ADRB2 Beta-2 adrenergic receptor

Protein Summary

Description

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P07550
• B0LPE4
• B2R7X2
• O14823
• O14824
• O14825
• O14826
• Q4JG18
• Q53GA6
• Q6GMT4
• Q6P4D8
• Q8NEQ9
• Q96EC3
• Q9UCZ0
• Q9UCZ1
• Q9UCZ2
• Q9UCZ3
• Q9UH95
• Q9UHA1
• Q9UMZ5

Gene Name

• ADRB2

Ensembl ID

• ENST00000305988
• ENSP00000305372
• ENSG00000169252

Symbol

• ADRB2R
• B2AR
• BAR
• B2AR
• ADRBR
• ADRB2R
• BETA2AR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
biological process	0.99
virus perturbation	0.99
gene perturbation	0.98
biological term	0.97

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Beta-2 Adrenergic Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Adrenoceptor / Beta Adrenoceptor / Beta-2 Adrenergic Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2901.4   (req: < 5)

Gene RIFs: 748   (req: <= 3)

Antibodies: 1027   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2901.4   (req: >= 5)

Gene RIFs: 748   (req: > 3)

Antibodies: 1027   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1087

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 48