Protein Summary
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates. This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
- ENST00000311737
- ENSP00000308720
- ENSG00000204983
- ENST00000616256
- ENSP00000479217
- ENSG00000274247
- TRP1
- TRY1
- TRYP1
- TRP1
- TRY1
- TRY4
- TRYP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
gene perturbation | 0.76 | ||
cell type or tissue | 0.73 | ||
cell line | 0.69 | ||
disease | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 692.87 (req: < 5)
Gene RIFs: 131 (req: <= 3)
Antibodies: 502 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 692.87 (req: >= 5)
Gene RIFs: 131 (req: > 3)
Antibodies: 502 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 889
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2