Tclin CA3 Carbonic anhydrase 3

Protein Summary

Description

Reversible hydration of carbon dioxide. Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P07451
• B2R867
• B3KUC8
• O60842

Gene Name

• CA3

Ensembl ID

• ENST00000285381
• ENSP00000285381
• ENSG00000164879

Symbol

• Car3
• CAIII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.9
PubMedID	0.83
gene perturbation	0.7
protein domain	0.58
chemical	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 850.5   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 383   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 850.5   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 383   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6