| Tdark | Acylphosphatase-1 |
Its physiological role is not yet clear.
This gene is a member of the acylphosphatase family. The encoded protein is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated and described based on their tissue localization: erythrocyte (common) type acylphosphatase encoded by this gene, and muscle type acylphosphatase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
This gene is a member of the acylphosphatase family. The encoded protein is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated and described based on their tissue localization: erythrocyte (common) type acylphosphatase encoded by this gene, and muscle type acylphosphatase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Comments
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.300 | 0.016 |
| osteosarcoma | -1.758 | 0.001 |
| glioblastoma | -1.300 | 0.004 |
| intraductal papillary-mucinous adenoma (... | 1.200 | 0.004 |
| intraductal papillary-mucinous carcinoma... | 1.700 | 0.001 |
| intraductal papillary-mucinous neoplasm ... | 2.000 | 0.005 |
| lung cancer | 1.600 | 0.001 |
| adult high grade glioma | -1.300 | 0.000 |
| pilocytic astrocytoma | -1.300 | 0.000 |
| aldosterone-producing adenoma | -1.068 | 0.026 |
| Pick disease | -1.300 | 0.000 |
| ovarian cancer | 1.300 | 0.020 |
| PMID | Text |
|---|---|
| 14992377 | two products of the ACYP1 gene are characterized as the result of alternative splicing in which an extra 79 bp long exon is inserted between the two known exons |
| 12409302 | Data show that CT acylphosphatase catalyzes the hydrolysis of aryl phosphates and acyl phosphates by two different mechanisms. |
| PMID | Year | Title |
|---|---|---|
| 23376485 | 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 19196981 | 2009 | Rational stabilization of enzymes by computational redesign of surface charge-charge interactions. |
| 16511269 | 2006 | Crystallization and preliminary crystallographic analysis of human common-type acylphosphatase. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 14992377 | 2004 | ACYP1 gene possesses two alternative splicing forms that induce apoptosis. |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 12508121 | 2003 | The DNA sequence and analysis of human chromosome 14. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| 12409302 | 2003 | A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase. |
| More... |
