You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
TH
Tyrosine 3-monooxygenase

Protein Summary
Description
Plays an important role in the physiology of adrenergic neurons. The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333684
  • ENSP00000328814
  • ENSG00000180176
  • ENST00000352909
  • ENSP00000325951
  • ENST00000381175
  • ENSP00000370567
  • ENST00000381178
  • ENSP00000370571

Symbol
  • TYH
  • TYH
  • DYT14
  • DYT5b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
kinase
0.99
molecular function
0.95
biological term
0.94


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2728.85   (req: < 5)
Gene RIFs: 162   (req: <= 3)
Antibodies: 1508   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2728.85   (req: >= 5)
Gene RIFs: 162   (req: > 3)
Antibodies: 1508   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 67
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1