Property Summary

NCBI Gene PubMed Count 178
PubMed Score 5615.43
PubTator Score 4955.22

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
glioblastoma 5572 5.37664356861541E-7
pilocytic astrocytoma 3086 4.83151051503323E-6
pediatric high grade glioma 2712 7.77927295101143E-4
sonic hedgehog group medulloblastoma 1482 8.07037772343343E-4
Down syndrome 548 0.00154939117465785
osteosarcoma 7933 0.00177243487896604
oligodendroglioma 2849 0.00279910731232505
Pick disease 1893 0.00307897329567526
ependymoma 2514 0.00415180642667772
astrocytic glioma 2241 0.00493784612123577
primitive neuroectodermal tumor 3031 0.0107679207877519
atypical teratoid/rhabdoid tumor 1095 0.0319849085683956
medulloblastoma, large-cell 6234 0.033295924032438
Disease Target Count
Pituitary apoplexy 3


  Differential Expression (13)

Disease log2 FC p
astrocytic glioma -3.000 0.005
ependymoma -3.500 0.004
oligodendroglioma -3.200 0.003
glioblastoma -3.000 0.000
osteosarcoma -2.545 0.002
sonic hedgehog group medulloblastoma -3.500 0.001
medulloblastoma, large-cell -1.300 0.033
primitive neuroectodermal tumor -2.400 0.011
pediatric high grade glioma -2.900 0.001
atypical teratoid/rhabdoid tumor -1.100 0.032
pilocytic astrocytoma -3.500 0.000
Pick disease -1.300 0.003
Down syndrome -2.000 0.002


Accession P06850 B3KQS4
Symbols CRF




3EHT   3EHU   1GOE  

  Ortholog (10)

Gene RIF (146)

26882083 These results suggest that the CRH and CRH-BP genes have no direct effect on Irritable bowel syndrome status.
26350463 results show that activation of CRH receptors by CRH ligands stimulates VEGF-A expression in intestinal epithelial cells through the cAMP/CREB pathway
26331704 Placenta CRH mRNA concentration appears to convey information about the risk of brain damage in the infant born at an extremely low gestational age.
26307012 results suggest that glucocorticoids induce a transcription complex consisting of RelB/p52, CBP, and HDAC1 that triggers a dynamic acetylation-mediated epigenetic change to induce CRH expression in full-term human placenta.
26212818 This corticotropin releasing factor-induced regulation on norepinephrine transporter expression and function may play a role in development of stress-related depression and anxiety
26074267 Data suggest that signal transduction involving corticotropin-releasing factor (CRH) and CRH receptors (CRHR) taking place in cochlea are involved in protecting against noise-induced hearing loss. [REVIEW]
26055202 This study evaluated the associations of CRH polymorphisms with susceptibility to MDD and response to antidepressant treatment
25771405 Interaction of RelB with the CRH or COX-2 gene promoters decreased when STAT3 was depleted.
25673853 we show that Abeta species can hyperexcite CRF neurons, providing a mechanism by which Abeta influences stress-related symptoms
25630718 the present study demonstrates that the expression of CRH/CRH-R1 in lesions of chronic plaque psoriasis is lower than that in psoriatic perilesional skin and normal control skin.

AA Sequence


Text Mined References (177)

PMID Year Title
26882083 2016 Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome.
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
26350463 2015 Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway.
26331704 2016 Brain disorders associated with corticotropin-releasing hormone expression in the placenta among children born before the 28th week of gestation.
26307012 2015 RelB/p52-mediated NF-?B signaling alters histone acetylation to increase the abundance of corticotropin-releasing hormone in human placenta.
26212818 2015 Corticotropin releasing factor up-regulates the expression and function of norepinephrine transporter in SK-N-BE (2) M17 cells.
26074267 2015 Cellular signaling protective against noise-induced hearing loss – A role for novel intrinsic cochlear signaling involving corticotropin-releasing factor?
26055202 2015 Association analysis for corticotropin releasing hormone polymorphisms with the risk of major depressive disorder and the response to antidepressants.
25771405 2015 STAT3 cooperates with the non-canonical NF-?B signaling to regulate pro-labor genes in the human placenta.
25673853 2015 Posttraumatic stress disorder-like induction elevates ?-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses.