Tbio TPM3 Tropomyosin alpha-3 chain

Protein Summary

Description

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• P06753
• D3DV71
• P12324
• Q2QD06
• Q5VU58
• Q5VU63
• Q5VU66
• Q5VU71
• Q5VU72
• Q8TCG3
• Q969Q2
• Q9NQH8

Gene Name

• TPM3

Ensembl ID

• ENST00000302206
• ENSP00000307712
• ENSG00000143549
• ENST00000323144
• ENSP00000357518
• ENST00000328159
• ENSP00000357520
• ENST00000330188
• ENSP00000339035
• ENST00000368530
• ENSP00000357516
• ENST00000368531
• ENSP00000357517
• ENST00000368533
• ENSP00000357521

Symbol

• TM3
• TM5
• TRK
• CFTD
• NEM1
• TM-5
• TM30
• CAPM1
• TM30nm
• TPM3nu
• TPMsk3
• hscp30
• HEL-189
• HEL-S-82p
• OK/SW-cl.5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.94
transcription factor perturbation	0.94
kinase perturbation	0.93
PubMedID	0.8
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Tropomyosin Alpha-3 Chain

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Tropomyosin Alpha-3 Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1004.39   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 211   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1004.39   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0