| Tbio | Nucleophosmin |
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029).
The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]
The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Adenocarcinoma of lung | 142 | 0.0 | 0.0 |
| Clinical Deterioration | 6 | 0.0 | 0.0 |
| Disease Models, Animal | 155 | 0.0 | 0.0 |
| Leukemia, Myeloid, Acute | 105 | 0.0 | 0.0 |
| Leukemia, Promyelocytic, Acute | 36 | 0.0 | 0.0 |
| Stomach Neoplasms | 300 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 8.8e-15 |
| lung adenocarcinoma | 2716 | 5.9e-14 |
| ependymoma | 4679 | 2.4e-10 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.1e-09 |
| glioblastoma | 5792 | 7.5e-09 |
| medulloblastoma, large-cell | 6241 | 1.8e-06 |
| adult high grade glioma | 3801 | 9.0e-06 |
| group 3 medulloblastoma | 4104 | 7.9e-05 |
| acute quadriplegic myopathy | 1158 | 1.6e-04 |
| primitive neuroectodermal tumor | 3035 | 2.7e-04 |
| psoriasis | 6694 | 4.6e-04 |
| lung cancer | 4740 | 2.1e-03 |
| Multiple myeloma | 1332 | 2.6e-03 |
| pancreatic cancer | 2398 | 4.0e-03 |
| diabetes mellitus | 1728 | 4.2e-03 |
| Waldenstrons macroglobulinemia | 765 | 6.1e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 6.7e-03 |
| oligodendroglioma | 2850 | 1.0e-02 |
| colon cancer | 1478 | 1.2e-02 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 2.1e-02 |
| acute myeloid leukemia | 783 | 3.5e-02 |
| subependymal giant cell astrocytoma | 2287 | 4.4e-02 |
| Disease | Target Count |
|---|---|
| Acute Promyelocytic Leukemia | 40 |
| Leukemia, Acute Myeloid | 17 |
| Lymphomatoid Papulosis | 2 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 1.200 | 3.5e-02 |
| acute quadriplegic myopathy | 1.044 | 1.6e-04 |
| adult high grade glioma | 1.300 | 9.0e-06 |
| atypical teratoid / rhabdoid tumor | 2.100 | 4.1e-09 |
| colon cancer | 1.800 | 1.2e-02 |
| diabetes mellitus | 1.400 | 4.2e-03 |
| ependymoma | 1.100 | 2.4e-10 |
| glioblastoma | 1.300 | 7.5e-09 |
| group 3 medulloblastoma | 1.400 | 7.9e-05 |
| lung adenocarcinoma | 1.100 | 5.9e-14 |
| lung cancer | 1.400 | 2.1e-03 |
| medulloblastoma, large-cell | 2.900 | 1.8e-06 |
| mucosa-associated lymphoid tissue lympho... | -1.012 | 2.1e-02 |
| Multiple myeloma | 1.809 | 2.6e-03 |
| non-small cell lung cancer | 1.017 | 8.8e-15 |
| oligodendroglioma | -1.100 | 1.0e-02 |
| pancreatic cancer | -1.600 | 4.0e-03 |
| primary pancreatic ductal adenocarcinoma | -1.538 | 6.7e-03 |
| primitive neuroectodermal tumor | 1.100 | 2.7e-04 |
| psoriasis | 1.300 | 4.6e-04 |
| subependymal giant cell astrocytoma | 1.289 | 4.4e-02 |
| Waldenstrons macroglobulinemia | 1.287 | 6.1e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
RPL26L1
RPL4
RPF1
CCDC137
RBM28
RPL7A
POP1
DDX24
FTSJ3
DDX21
HJURP
RPL3
ZFP62
DDX56
DDX27
GLYR1
NCL
MAK16
REXO4
DDX31
MYBBP1A
NEPRO
RRP8
GNL2
PAPD5
SURF6
GTPBP4
PUM3
NOP2
NVL
NOP53
URB1
RPL23A
TEX10
NOC3L
BRIX1
RBM34
NMNAT1
CENPC
SENP5
RPL36AL
ZNF800
RPL7L1
RPF2
NOC2L
RPP40
DDX51
PPAN-P2RY11
RPP38
RPP25
NPM3
SPTY2D1
RPP25L
POP7
MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGS 1 - 70 PIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISG 71 - 140 KRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQKSNQN 141 - 210 GKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTD 211 - 280 QEAIQDLWQWRKSL 281 - 294 //
