| Tclin | Progesterone receptor |
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
Comments
Property Summary
| NCBI Gene PubMed Count | 601 |
| Grant Count | 1,059 |
| R01 Count | 514 |
| Funding | $132,497,799.41 |
| PubMed Score | 7682.56 |
| PubTator Score | 5388.46 |
| Disease | log2 FC | p |
|---|---|---|
| intraductal papillary-mucinous adenoma (... | -1.100 | 0.001 |
| intraductal papillary-mucinous carcinoma... | -1.300 | 0.000 |
| intraductal papillary-mucinous neoplasm ... | -1.100 | 0.007 |
| colon cancer | -1.100 | 0.003 |
| lung cancer | -1.500 | 0.001 |
| interstitial cystitis | -2.100 | 0.000 |
| posterior fossa group B ependymoma | 1.300 | 0.000 |
| Breast cancer | -2.000 | 0.028 |
| invasive ductal carcinoma | -2.300 | 0.007 |
| ovarian cancer | -4.200 | 0.000 |
hydroxyprogesterone caproate
pIC50 7.66
progesterone
ED50 9.88
norethindrone acetate
ED50 11.26
norethisterone
ED50 11.26
mifepristone
pKi 8.74
medroxyprogesterone
pEC50 9.59
levonorgestrel
ED50 12.80
drospirenone
pEC50 10.50
dydrogesterone
pKi 6.90
ulipristal
pIC50 9.70
CHEMBL26763
pIC50 7.00
CHEMBL24583
pIC50 7.00
CHEMBL24689
pIC50 7.00
CHEMBL486910
pIC50 7.00
CHEMBL93451
pKi 7.00
CHEMBL294116
pIC50 7.00
CHEMBL519394
pIC50 7.00
CHEMBL417110
pIC50 7.00
CHEMBL190264
pKi 7.00
CHEMBL28164
pIC50 7.00
CHEMBL8637
pKi 7.00
CHEMBL25292
pIC50 7.00
CHEMBL589854
pIC50 7.00
CHEMBL590835
pIC50 7.00
CHEMBL3120320
pKi 7.00
CHEMBL26764
pIC50 7.00
CHEMBL1164339
pKi 7.00
CHEMBL364924
pKi 7.00
CHEMBL344135
pIC50 7.00
CHEMBL343410
pIC50 7.00
| AID | Type | Active / Inconclusive / Inactive | Description |
|---|---|---|---|
| 2277 | screening |
14 / 0 / 0 | Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. |
| 504934 | other |
1 / 0 / 0 | Late stage assay provider results from the probe development effort to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors |
| PMID | Text |
|---|---|
| 27069179 | Neural Analyses Validate and Emphasize the Role of Progesterone Receptor in Breast Cancer Progression and Prognosis |
| 26916548 | progesterone acts via the progesterone receptor to modulate ADAMTS 1 and 4 levels in ovarian cancer cell lines. |
| 26892043 | Data demonstrated the significance of PR extranuclear signaling through PPD interactions in EGFR-mediated proliferation and signaling in NSCLC. |
| 26829108 | the MapQuanttrade mark assay, based on mRNA expression assay, provides an objective and quantitative assessment of Estrogen receptor, Progesterone receptor and HER2 status in invasive breast cancer. |
| 26820652 | TargetPrint ER had a positive agreement of 98 %, and a negative agreement of 95 % with central pathology. Corresponding figures for PgR were 85 and 94 % and for HER-2 72 and 99 %. Agreement of mRNA versus central protein was not different when the same or a different portion of the tumor tissue was analyzed or when DCIS and/or normal tissue was included in the sample subjected to mRNA assays |
| 26579819 | Analysis of patients with ER-/PgR+/HER2- breast cancers showed that this subtype exhibited an aggressive behavior compared to triple negative breast cancers. |
| 26577046 | Study indicate that PR-B isoform is the dominant driver of cellular senescence in ovarian cancer cells and reveal that dephosphorylated FOXO1 confers potent PR-B-like transcriptional activity to PR-A and is required for its phosphorylation on Ser294 and transactivation of PR-B. |
| 26550991 | Estrogen receptor, progesterone receptor or human epidermal growth factor receptor 2 samples with high-methylation risk score had the worst 5-year survival rate and overall survival time. |
| 26517007 | findings suggest that human labour may develop as a consequence of a decline in mPR(alpha+) Treg cells, which reduces progesterone anti-inflammatory action through Treg cells. |
| 26458823 | Rs11571215 in PGR (progesterone receptor) was the SNP most strongly associated with ER- disease. |
| More... |
MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPS 1 - 70 DEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSW 71 - 140 CLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPV 141 - 210 KPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRV 211 - 280 ALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASS 281 - 350 TPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG 351 - 420 PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLL 421 - 490 PRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFE 491 - 560 SLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQA 561 - 630 GMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIY 631 - 700 AGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKH 701 - 770 VSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ 771 - 840 FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMS 841 - 910 EVIAAQLPKILAGMVKPLLFHKK 911 - 933 //
| PMID | Year | Title |
|---|---|---|
| 27069179 | 2016 | Neural Analyses Validate and Emphasize the Role of Progesterone Receptor in Breast Cancer Progression and Prognosis. |
| 26916548 | 2016 | Progesterone acts via the progesterone receptor to induce adamts proteases in ovarian cancer cells. |
| 26892043 | 2016 | Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells. |
| 26829108 | 2016 | Estrogen-Receptor, Progesterone-Receptor and HER2 Status Determination in Invasive Breast Cancer. Concordance between Immuno-Histochemistry and MapQuant™ Microarray Based Assay. |
| 26820652 | 2016 | Discordant assessment of tumor biomarkers by histopathological and molecular assays in the EORTC randomized controlled 10041/BIG 03-04 MINDACT trial breast cancer : Intratumoral heterogeneity and DCIS or normal tissue components are unlikely to be the cause of discordance. |
| 26579819 | 2015 | Prognostic Significance of Single Progesterone Receptor Positivity: A Comparison Study of Estrogen Receptor Negative/Progesterone Receptor Positive/Her2 Negative Primary Breast Cancer With Triple Negative Breast Cancer. |
| 26577046 | 2016 | Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming. |
| 26550991 | 2015 | DNA Methylation Patterns Can Estimate Nonequivalent Outcomes of Breast Cancer with the Same Receptor Subtypes. |
| 26517007 | 2016 | Can membrane progesterone receptor ? on T regulatory cells explain the ensuing human labour? |
| 26458823 | 2015 | Hormone-related pathways and risk of breast cancer subtypes in African American women. |
| More... |
