| Tclin | Progesterone receptor |
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
Comments
Property Summary
| Ligand Count | 630 |
| NCBI Gene PubMed Count | 636 |
| PubMed Score | 7951.25 |
| PubTator Score | 5388.46 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Carcinoma | 11493 | 5.987 | 3.0 |
| Meningioma | 41 | 4.625 | 2.3 |
| Adenocarcinoma | 122 | 0.0 | 0.0 |
| Breast Neoplasms | 445 | 0.0 | 0.0 |
| Endometrial Neoplasms | 55 | 0.0 | 0.0 |
| Mammary Neoplasms, Animal | 136 | 0.0 | 0.0 |
| Mammary Neoplasms, Experimental | 154 | 0.0 | 0.0 |
| Mesothelioma | 38 | 0.0 | 0.0 |
| Progesterone Resistance | 1 | 0.0 | 0.0 |
| Recurrence | 33 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 2.0e-08 |
| posterior fossa group B ependymoma | 416 | 2.2e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 4.1e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 8.1e-04 |
| lung cancer | 4740 | 8.2e-04 |
| interstitial cystitis | 2312 | 1.1e-03 |
| colon cancer | 1478 | 2.8e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 6.8e-03 |
| invasive ductal carcinoma | 2951 | 7.4e-03 |
| Breast cancer | 3578 | 2.8e-02 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | -2.000 | 2.8e-02 |
| ovarian cancer | -4.200 | 2.0e-08 |
| colon cancer | -1.100 | 2.8e-03 |
| interstitial cystitis | -1.700 | 1.1e-03 |
| intraductal papillary-mucinous adenoma (... | -1.100 | 8.1e-04 |
| intraductal papillary-mucinous carcinoma... | -1.300 | 4.1e-04 |
| intraductal papillary-mucinous neoplasm ... | -1.100 | 6.8e-03 |
| invasive ductal carcinoma | -2.300 | 7.4e-03 |
| lung cancer | -1.500 | 8.2e-04 |
| posterior fossa group B ependymoma | 1.300 | 2.2e-04 |
hydroxyprogesterone caproate
pIC50 7.66
progesterone
ED50 9.88
norethindrone acetate
ED50 11.26
mifepristone
pKi 8.74
medroxyprogesterone
pEC50 9.59
levonorgestrel
ED50 12.80
drospirenone
pEC50 10.50
dydrogesterone
pKi 6.90
ulipristal
pIC50 9.70
fulvestrant
pIC50 9.68
CHEMBL26763
pIC50 7.00
CHEMBL24583
pIC50 7.00
CHEMBL24689
pIC50 7.00
CHEMBL486910
pIC50 7.00
CHEMBL93451
pKi 7.00
CHEMBL294116
pIC50 7.00
CHEMBL519394
pIC50 7.00
CHEMBL417110
pIC50 7.00
CHEMBL190264
pKi 7.00
CHEMBL28164
pIC50 7.00
CHEMBL8637
pKi 7.00
CHEMBL25292
pIC50 7.00
CHEMBL589854
pIC50 7.00
CHEMBL590835
pIC50 7.00
CHEMBL3120320
pKi 7.00
CHEMBL26764
pIC50 7.00
CHEMBL1164339
pKi 7.00
CHEMBL364924
pKi 7.00
CHEMBL344135
pIC50 7.00
CHEMBL343410
pIC50 7.00
MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPS 1 - 70 DEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSW 71 - 140 CLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPV 141 - 210 KPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRV 211 - 280 ALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASS 281 - 350 TPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG 351 - 420 PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLL 421 - 490 PRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFE 491 - 560 SLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQA 561 - 630 GMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIY 631 - 700 AGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKH 701 - 770 VSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ 771 - 840 FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMS 841 - 910 EVIAAQLPKILAGMVKPLLFHKK 911 - 933 //
