Tclin FYN Tyrosine-protein kinase Fyn

Protein Summary

Description

Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P06241
• B5BU57
• E1P557
• H0UI48
• Q16248
• Q5R3A6
• Q5R3A7
• Q8N5D7

Gene Name

• FYN

Ensembl ID

• ENST00000229471
• ENSP00000229471
• ENSG00000010810
• ENST00000354650
• ENSP00000346671
• ENST00000368667
• ENSP00000357656
• ENST00000368678
• ENSP00000357667
• ENST00000368682
• ENSP00000357671
• ENST00000538466
• ENSP00000440646

Symbol

• SLK
• SYN
• p59-FYN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	1
molecular function	1
virus	1
viral protein	0.98

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Src Family / Tyrosine-protein Kinase Fyn

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1383.47   (req: < 5)

Gene RIFs: 184   (req: <= 3)

Antibodies: 933   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1383.47   (req: >= 5)

Gene RIFs: 184   (req: > 3)

Antibodies: 933   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 84

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 75

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5