Property Summary

NCBI Gene PubMed Count 108
PubMed Score 1058.79
PubTator Score 401.67

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Myopathy 128
Necrosis 51
Disease Target Count P-value
malignant mesothelioma 3163 4.94498049380315E-10
lung carcinoma 2844 7.23596324625939E-10
atypical teratoid / rhabdoid tumor 4369 8.93528037635127E-9
osteosarcoma 7933 2.71596544130843E-6
juvenile dermatomyositis 1189 5.28991196184507E-6
medulloblastoma 1524 9.12461828943593E-6
glioblastoma 5572 1.08464260213957E-5
acute quadriplegic myopathy 1157 1.25446004656979E-5
lung cancer 4473 1.48451989801021E-5
psoriasis 6685 1.77775584733501E-4
pilocytic astrocytoma 3086 2.8422742088624E-4
medulloblastoma, large-cell 6234 4.27428093097425E-4
Pick disease 1893 5.63944815154379E-4
primitive neuroectodermal tumor 3031 7.81629875183838E-4
active ulcerative colitis 477 0.00118322766793634
adult high grade glioma 2148 0.00126281378504
dermatomyositis 967 0.00216825078789255
limb girdle muscular dystrophy 2A 156 0.00244753587811477
active Crohn's disease 918 0.00307033034822471
astrocytic glioma 2241 0.00381889456763827
pituitary cancer 1972 0.0042537054222916
ependymoma 2514 0.00586385383845046
oligodendroglioma 2849 0.00696836679215505
gastric carcinoma 832 0.0432198196691098
mucosa-associated lymphoid tissue lymphoma 480 0.0474773530553076


  Differential Expression (25)

Disease log2 FC p
malignant mesothelioma 5.700 0.000
astrocytic glioma -2.900 0.004
ependymoma -3.100 0.006
oligodendroglioma -2.700 0.007
psoriasis -3.000 0.000
glioblastoma -3.200 0.000
osteosarcoma -3.073 0.000
medulloblastoma -3.000 0.000
atypical teratoid / rhabdoid tumor -3.600 0.000
medulloblastoma, large-cell -3.500 0.000
primitive neuroectodermal tumor -2.800 0.001
juvenile dermatomyositis -1.313 0.000
acute quadriplegic myopathy -2.019 0.000
limb girdle muscular dystrophy 2A -1.137 0.002
lung cancer -3.100 0.000
active Crohn's disease -1.104 0.003
active ulcerative colitis -1.472 0.001
adult high grade glioma -2.600 0.001
pilocytic astrocytoma -2.100 0.000
lung carcinoma -2.400 0.000
Pick disease -1.200 0.001
gastric carcinoma -1.200 0.043
mucosa-associated lymphoid tissue lympho... 2.619 0.047
pituitary cancer 1.100 0.004
dermatomyositis -1.300 0.002


Accession P05413 B2RAB6 Q5VV93 Q99957
Symbols MDGI



1G5W   1HMR   1HMS   1HMT   2HMB   3RSW   3WBG   3WVM   3WXQ   4TJZ   4TKB   4TKH   4TKJ   4WBK   5CE4  

  Ortholog (6)

Species Source
Chimp OMA EggNOG
Mouse OMA Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Xenopus OMA EggNOG

Gene RIF (84)

26484922 This study demonstrated that CSF FABP-3 may be an early marker for later development of dementia.
26212703 Bedside H-FABP measurements may contribute to correct early diagnoses, as its levels are elevated soon following myocardial infarction, and measurement is easy, with a rapid result.
26206228 polymorphism affects fatty acid-binding protein 3 intracellular stability and subcellular localization
26072112 FABP3 was increased in patients with acute heart failure compared to those without.
25830762 Perioperative plasma H-FABP levels may be used for risk stratification of acute kidney injury and mortality following cardiac surgery.
25456730 H-FABP may have a role in occurrence of adverse clinical outcome in pulmonary embolism [meta-analysis]
25234940 Serum H-FABP levels progressively increased from the control group to the OH group.
25212385 Report correlation between preoperative serum h-FABP and the postoperative incidence of acute kidney injury in cardiac surgery patients.
25147067 Elevated H-FABP serum levels in patients with essential hypertension were predictive of future cardiovascular events.
25027319 The frameshift and missense mutations in FABP3, FABP5, and FABP7 genes have been identified in schizophrenia and autism spectrum disorder in humans and in mouse behavioral studies.

AA Sequence


Text Mined References (111)

PMID Year Title
26484922 2016 Cerebrospinal Fluid Fatty Acid-Binding Protein 3 is Related to Dementia Development in a Population-Based Sample of Older Adult Women Followed for 8 Years.
26212703 Comparison of a qualitative measurement of heart-type fatty acid-binding protein with other cardiac markers as an early diagnostic marker in the diagnosis of non-ST-segment elevation myocardial infarction.
26206228 2015 Asp3Gly polymorphism affects fatty acid-binding protein 3 intracellular stability and subcellular localization.
26072112 2015 Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I.
25830762 2015 Perioperative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery.
25456730 2015 Prognostic role of heart-type fatty acid binding protein in pulmonary embolism: a meta-analysis.
25416956 2014 A proteome-scale map of the human interactome network.
25234940 2014 Serum H-FABP levels in patients with hypothyroidism.
25212385 2014 Preoperative serum h-FABP concentration is associated with postoperative incidence of acute kidney injury in patients undergoing cardiac surgery.
25147067 2014 Heart-type fatty acid-binding protein is a novel prognostic marker in patients with essential hypertension.