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Tbio
SCG5
Neuroendocrine protein 7B2

Protein Summary
Description
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. This gene also produces a ARHGAP11A-SCG5 readthrough trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300175
  • ENSP00000300175
  • ENSG00000166922
  • ENST00000413748
  • ENSP00000388560
  • ENST00000614359
  • ENSP00000482615
  • ENSG00000277614
  • ENST00000632219
  • ENSP00000488109
  • ENSG00000281931
  • ENST00000632674
  • ENSP00000488509

Symbol
  • SGNE1
  • 7B2
  • SgV
  • P7B2
  • SGNE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
molecular function
0.86
PubMedID
0.81
small molecule perturbation
0.77
phenotype
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.09   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.09   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0