Tchem ALPL Alkaline phosphatase, tissue-nonspecific isozyme

Protein Summary

Description

This isozyme may play a role in skeletal mineralization. This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P05186
• A1A4E7
• B2RMP8
• B7Z387
• B7Z4Y6
• O75090
• Q2TAI7
• Q59EJ7
• Q5BKZ5
• Q5VTG5
• Q6NZI8
• Q8WU32
• Q9UBK0
• AP-TNAP

Gene Name

• ALPL

Ensembl ID

• ENST00000374832
• ENSP00000363965
• ENSG00000162551
• ENST00000374840
• ENSP00000363973
• ENST00000539907
• ENSP00000437674
• ENST00000540617
• ENSP00000442672

Symbol

• HOPS
• TNAP
• TNALP
• APTNAP
• TNSALP
• AP-TNAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.91
chemical	0.87
phenotype	0.85
PubMedID	0.79
transcription factor binding site profile	0.74

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Alkaline Phosphatase, Tissue-nonspecific Isozyme

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Alkaline Phosphatase, Tissue-nonspecific Isozyme

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 785.11   (req: < 5)

Gene RIFs: 201   (req: <= 3)

Antibodies: 934   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 785.11   (req: >= 5)

Gene RIFs: 201   (req: > 3)

Antibodies: 934   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 116

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0