| Tbio | Plasminogen activator inhibitor 2 |
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Breast Neoplasms | 445 | 0.0 | 0.0 |
| Non-alcoholic Fatty Liver Disease | 42 | 0.0 | 0.0 |
| Peripheral Nervous System Diseases | 52 | 0.0 | 0.0 |
| Stomach Neoplasms | 300 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Mammary Neoplasms | 425 |
| Peripheral Neuropathy | 134 |
| Disease | Target Count | P-value |
|---|---|---|
| nasopharyngeal carcinoma | 1058 | 1.9e-09 |
| malignant mesothelioma | 3232 | 1.1e-08 |
| cystic fibrosis | 1696 | 1.8e-08 |
| tuberculosis | 2010 | 1.6e-05 |
| non-small cell lung cancer | 2890 | 6.4e-05 |
| pancreatic cancer | 2398 | 6.6e-04 |
| Atopic dermatitis | 952 | 4.1e-03 |
| psoriasis | 6694 | 5.0e-03 |
| uncontrolled asthma | 56 | 5.4e-03 |
| osteosarcoma | 7950 | 5.8e-03 |
| interstitial cystitis | 2312 | 9.8e-03 |
| esophageal adenocarcinoma | 737 | 2.3e-02 |
| gastric cancer | 459 | 2.8e-02 |
| spina bifida | 1074 | 4.4e-02 |
| Disease | log2 FC | p |
|---|---|---|
| Atopic dermatitis | -1.400 | 4.1e-03 |
| cystic fibrosis | 5.361 | 1.8e-08 |
| esophageal adenocarcinoma | -3.900 | 2.3e-02 |
| gastric cancer | -1.200 | 2.8e-02 |
| interstitial cystitis | 1.800 | 9.8e-03 |
| malignant mesothelioma | -4.000 | 1.1e-08 |
| nasopharyngeal carcinoma | -3.500 | 1.9e-09 |
| non-small cell lung cancer | 1.979 | 6.4e-05 |
| osteosarcoma | -1.366 | 5.8e-03 |
| pancreatic cancer | 2.400 | 6.6e-04 |
| psoriasis | 1.300 | 5.0e-03 |
| spina bifida | -1.375 | 4.4e-02 |
| tuberculosis | -5.600 | 1.6e-05 |
| uncontrolled asthma | 2.300 | 5.4e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG |
MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGANAVTP 1 - 70 MTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREE 71 - 140 YIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKT 141 - 210 PFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLE 211 - 280 LLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLF 281 - 350 LSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP 351 - 415 //
