Property Summary

NCBI Gene PubMed Count 992
PubMed Score 8890.74
PubTator Score 6054.65

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Ischemic stroke 12



Accession P05112 Q14630 Q6NZ77 IL-4
Symbols BSF1




3BPN   1IAR   1ITE   3BPL   1BBN   1BCN   1CYL   1HIJ   1HIK   1HZI   1ILL   1ITI   1ITL   1ITM   1RCB   2B8U   2B8X   2B8Y   2B8Z   2B90   2B91   2CYK   2D48   2INT   3QB7   4YDY   5FHX  

  Ortholog (5)

Gene RIF (1084)

27080531 Interleukin-4 used with GM-CSF and TNF-alpha during the maturation of DCs in vitro impaired dendritic cells (DC) functions.
26927386 Data show that during chronic HBV infection, interferon gamma (IFN-gamma) and interleukin 4 (IL-4 )expressed by peripheral blood T cells play dual immunoregulatory roles, which are correlated with the efficacy of entecavir.
26879815 Reported is the distribution of allelic and genotypic frequencies of IL1A, IL4, NFKB1 and PAR1 variants in Native American, African, and European populations of Brazil and their association with predisposition to cancer.
26861613 The IL-4 rs79071878 polymorphism, was associated whereas the IL-1Ra rs2234663 polymorphism was not associated with Familial Mediterranean Fever risk in the Turkish population.
26831416 investigated five SNPs (C-589T and C-33T of IL4, G+2044A of IL13, A+1902G of IL4Ralpha, and A+896G of TLR4) in patients with adult onset asthma to evaluate their role in manifestation and severity of asthma
26829670 interleukin-4 regulates hematopoietic lineage choice by activating the JAK3-STAT6 pathway, which causes dendritic-cell-specific DNA demethylation
26758199 A constitutively activated form of STAT6 is able to bypass IL-4 upstream signalling and instruct dendritic-cell-specific functional DNA methylation changes
26755820 By regulating the polymerase III activity, IL-4 potently decreased the biogenesis of tRNA-Glu and, subsequently, td-piR(Glu).
26751822 IL4 expression in follicular fluid and follicular fluid lymphocytes of PCOS patients is not significantly different from controls.
26732352 Analysis of peripheral leucocytes, eosinophils, immunoglobulin E, and IL-4 and IL-10 concentrations presented significantly higher values in children with radiologically confirmed liver granuloma than in uncomplicated hepatomegaly.

AA Sequence

KTIMREKYSKCSS                                                             141 - 153

Text Mined References (992)

PMID Year Title
27080531 2016 Unexpected impairment of TNF-?-induced maturation of human dendritic cells in vitro by IL-4.
26927386 2016 [Alterations of IFN-? and IL-4 of peripheral blood T cells in patients with chronic HBV infection].
26879815 2016 Distribution of allelic and genotypic frequencies of IL1A, IL4, NFKB1 and PAR1 variants in Native American, African, European and Brazilian populations.
26861613 2016 Interleukin-1Ra rs2234663 and Interleukin-4 rs79071878 Polymorphisms in Familial Mediterranean Fever.
26831416 2015 A preliminary study on the association of single nucleotide polymorphisms of interleukin 4 (IL4), IL13, IL4 receptor alpha (IL4R?) & Toll-like receptor 4 (TLR4) genes with asthma in Indian adults.
26829670 2016 External signals shape the epigenome.
26758199 2016 IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation.
26755820 2016 IL-4 Inhibits the Biogenesis of an Epigenetically Suppressive PIWI-Interacting RNA To Upregulate CD1a Molecules on Monocytes/Dendritic Cells.
26751822 2016 Differential Expression Profile of Immunological Cytokines in Local Ovary in Patients with Polycystic Ovarian Syndrome: analysis by Flow Cytometry.
26732352 2016 Production of interleukins 4 and 10 in children with hepatic involvement in the course of Toxocara spp. infection.