Tclin ITGB2 Integrin beta-2

Protein Summary

Description

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• P05107
• B3KTS8
• D3DSM1
• Q16418
• Q53HS5
• Q9UD72

Gene Name

• ITGB2

Ensembl ID

• ENST00000302347
• ENSP00000303242
• ENSG00000160255
• ENST00000355153
• ENSP00000347279
• ENST00000397850
• ENSP00000380948
• ENST00000397852
• ENSP00000380950
• ENST00000397857
• ENSP00000380955

Symbol

• CD18
• MFI7
• LAD
• CD18
• MF17
• MFI7
• LCAMB
• LFA-1
• MAC-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
protein domain	0.92
disease	0.89
kinase perturbation	0.84
biological term	0.8

Protein Classes

PANTHER Classes

Protein / Receptor / Integrin Beta-2

Protein / Cell Adhesion Molecule / Integrin Beta-2

DTO Classes

Protein / Receptor / Integrin Beta-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 535.46   (req: < 5)

Gene RIFs: 394   (req: <= 3)

Antibodies: 1847   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 535.46   (req: >= 5)

Gene RIFs: 394   (req: > 3)

Antibodies: 1847   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1