Property Summary

NCBI Gene PubMed Count 2,176
Grant Count 2,500
R01 Count 1,330
Funding $325,685,516.09
PubMed Score 4118.95
PubTator Score 9905.46

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (54)

Disease Z-score Confidence
Alzheimer's disease 644 7.921 4.0
Dementia 129 5.677 2.8
Amyloidosis 68 5.476 2.7
Down syndrome 548 4.815 2.4
Cancer 2,346 4.71 2.4
Toxic encephalopathy 131 4.302 2.2
Inclusion body myositis 12 3.893 1.9
Brain disease 83 3.556 1.8
ALZHEIMER DISEASE, FAMILIAL, 1 1
Alzheimer Disease, Early-Onset, With Cer... 1 
Amnesia 17
Anxiety Disorders 37
Brain Diseases 22
Breast cancer 3,094
CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED 1
Cerebral amyloid angiopathy 9
Cerebral hemorrhage with amyloidosis, he... 1 
Chronic obstructive pulmonary disease 146 1.0
Cognition Disorders 23
Fragile X syndrome 31
Hereditary Cerebral Amyloid Angiopathy, ... 1 
Learning Disorders 27
Memory Disorders 36
Methemoglobinemia 17
Mild cognitive disorder 1
Muscle Weakness 92
Necrosis 51
Nerve Degeneration 73
Neurodegenerative Disorders 37
Neurodegenerative disease 383 4.0
Neurogenic Inflammation 12
Paralysed 9
Pick disease 1,893
Plaque, Amyloid 2
Polycystic Ovary Syndrome 332
Positron emission tomography 1
Premature aging syndrome 3
Rheumatoid Arthritis 1,160
Spinal Cord Diseases 3
Weight Gain 87
astrocytic glioma 2,241
atypical teratoid / rhabdoid tumor 4,369
autosomal dominant Emery-Dreifuss muscul... 499 
dermatomyositis 933
ependymoma 2,514
group 3 medulloblastoma 2,254
head and neck cancer and chronic obstruc... 237 
juvenile dermatomyositis 1,189
lung carcinoma 2,844
medulloblastoma, large-cell 6,234
oligodendroglioma 2,849
osteosarcoma 7,933
ovarian cancer 8,484
psoriasis 6,685

Expression

  Differential Expression (18)

Disease log2 FC p
Rheumatoid Arthritis 1.200 0.044
astrocytic glioma -1.100 0.004
ependymoma 1.200 0.023
oligodendroglioma 1.500 0.006
psoriasis -1.300 0.001
osteosarcoma 1.462 0.000
atypical teratoid / rhabdoid tumor -1.300 0.004
medulloblastoma, large-cell -1.900 0.001
autosomal dominant Emery-Dreifuss muscul... 1.222 0.007
juvenile dermatomyositis 1.384 0.000
Breast cancer 2.400 0.033
group 3 medulloblastoma -1.900 0.001
Polycystic Ovary Syndrome 1.120 0.005
lung carcinoma 1.100 0.000
Pick disease -1.100 0.000
ovarian cancer 1.700 0.003
dermatomyositis 1.200 0.023
head and neck cancer and chronic obstruc... -1.200 0.014

Synonym

Gene

APP

PANTHER Protein Class (1)