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Tbio
SLC4A2
Anion exchange protein 2

Protein Summary
Description
Plasma membrane anion exchange protein of wide distribution. This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary biliary cirrhosis (PBC) in human patients, while differential expression of this gene may be associated with malignant hepatocellular carcinoma, colon and gastric cancers. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392826
  • ENSP00000376571
  • ENSG00000164889
  • ENST00000413384
  • ENSP00000405600
  • ENST00000461735
  • ENSP00000419164
  • ENST00000485713
  • ENSP00000419412

Symbol
  • AE2
  • EPB3L1
  • HKB3
  • MPB3L
  • AE2
  • HKB3
  • BND3L
  • NBND3
  • EPB3L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
disease perturbation
0.9
transcription factor
0.86
transcription factor binding site profile
0.73
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.23   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.23   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0