Tclin AMY2A Pancreatic alpha-amylase

Protein Summary

Description

This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. This gene and several family members are present in a gene cluster on chromosome 1. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P04746
• B9EJG1
• Q9UBH3
• PA

Gene Name

• AMY2A

Ensembl ID

• ENST00000414303
• ENSP00000397582
• ENSG00000243480
• ENST00000622339
• ENSP00000481450

Symbol

• PA
• AMY2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
protein domain	0.97
drug	0.72
disease	0.52
molecular function	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 908.99   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 407   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 908.99   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 407   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1