Tchem AMY1A Alpha-amylase 1

Protein Summary

Description

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P04745
• A6NJS5
• A8K8H6
• Q13763
• Q5T083

Gene Name

• AMY1A

Ensembl ID

• ENST00000330330
• ENSP00000330484
• ENSG00000174876
• ENST00000370079
• ENSP00000359096
• ENSG00000187733
• ENST00000370080
• ENSP00000359097
• ENST00000370083
• ENSP00000359100
• ENSG00000237763

Symbol

• AMY1
• AMY1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.75
tissue sample	0.66
cell line	0.62
protein complex	0.4
cell type or tissue	0.38

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 599.34   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 303   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 599.34   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1