Property Summary

NCBI Gene PubMed Count 29
PubMed Score 40.10
PubTator Score 146.72

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
non-small cell lung cancer 2798 7.09232199564455E-14
malignant mesothelioma 3163 4.47626029275271E-10
acute quadriplegic myopathy 1157 3.15018743466625E-9
atypical teratoid/rhabdoid tumor 1095 7.58546381410481E-9
sonic hedgehog group medulloblastoma 1482 3.18927596298997E-8
ulcerative colitis 2087 1.27574030654045E-7
lung adenocarcinoma 2714 4.01609801553266E-7
ovarian cancer 8492 7.33864983016603E-6
colon cancer 1475 8.91000748289847E-6
lung cancer 4473 1.22617334689238E-5
breast carcinoma 1614 3.4573837091116E-5
medulloblastoma, large-cell 6234 4.49661392104887E-5
inflammatory breast cancer 404 0.00465290823691023
osteosarcoma 7933 0.00575603484296766
adrenocortical carcinoma 1427 0.007193833867877
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00790664969607501
Down syndrome 548 0.0113214828177689
pancreatic cancer 2300 0.0163015503094833
primary pancreatic ductal adenocarcinoma 1271 0.0178149725816113
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0231234105640193
facioscapulohumeral dystrophy 286 0.0298525774825973
Endometriosis 535 0.0310884611125704
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0324985559377326



Accession P04732 A2RRF7 Q86YX4 Q8TD51 MT-1E
Symbols MT1


Gene RIF (9)

22843066 MT1E can enhance the migration and invasion of human glioma cells by inducing MMP-9 inactivation via the upregulation of NF-kappaB p50.
21358552 Our results reveal that menopause influences the adipose tissue expression of many genes, especially of neurexin 3, metallothionein 1E, and keratyn 7, which are associated with the alteration of several key biological processes.
20848733 MT1E is a potential tumour suppressor gene, whose loss may promote resistance to apoptosis-inducing therapies.
20551211 Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia.
19420986 High frequency of hypermethylation of MT-1E was found in endometrial carcinomas.
18724390 analysis identified genes known to be associated with cell invasion such as versican, and novel ones, including metallothionein 1E (MT1E) and nicotinamide N-methyltransferase (NNMT)
18349110 Observational study of gene-disease association. (HuGE Navigator)
15747776 Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Heavy metal ion transporter activity.
12539042 Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection

AA Sequence


Text Mined References (31)

PMID Year Title
22843066 2012 Role of metallothionein 1E in the migration and invasion of human glioma cell lines.
21358552 2011 Profile of adipose tissue gene expression in premenopausal and postmenopausal women: site-specific differences.
20848733 2010 Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis.
20551211 2010 Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.
19420986 2009 Epigenetic alteration of the metallothionein 1E gene in human endometrial carcinomas.
18724390 2008 Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration.
18349110 2008 Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.
17244347 2007 Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16827180 2006 Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes.