Property Summary

NCBI Gene PubMed Count 45
Grant Count 32
R01 Count 25
Funding $5,526,905.64
PubMed Score 141.77
PubTator Score 22.40

Knowledge Summary

Patent

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Expression

Gene RIF (27)

PMID Text
26092210 Studies indicate that ribonucleotide reductase M1 polypeptide (RRM1) expression is associated with the response rate and overall survival rate of advanced NSCLC patients treated with gemcitabine-based chemotherapy.
25649960 The expressed human protamine1 in two fast-growing cell systems, E. coli and HeLa cells. The protamine 1 expression significantly attenuated cell proliferation when compared with control cells.
25536093 the quantity of PRM1, PRM2, and TNP2 transcripts and the PRM1/PRM2 mRNA ratio affect spermiogenesis, sperm morphology
23079002 genetic association study in Han population in China: Data suggest that an SNP in PRM1 (rs35576928; T allele; 34R>S) is associated with severe oligozoospermia and can play a protective role against this disease.
22574365 The SNP of PRM1-190C- > A might be associated with teratozoospermia-induced male infertility in the Han Chinese.
22472940 significant correlation has been found between protamine 1 and 2 transcripts/proteins and: sperm concentration, progressive sperm motility, sperm fertilization ability as well as embryo quality
22104739 Single nuclotide polymorphisms in PRM1 gene is associated with male infertility.
21317160 Data suggest that Casp4, Casp 6 and TNFSF10 are differentially expressed in potentially fertile and subfertile men and represent useful biomarkers for predicting male fertility in combination with P1 and P2.
21029114 identified and we report for the first time five novel rare haplotypes encompassing the protamine 1 and 2 genes
20378615 Observational study of gene-disease association. (HuGE Navigator)
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AA Sequence

MARYRCCRSQSRSRYYRQRQRSRRRRRRSCQTRRRAMRCCRPRYRPRCRRH                         1 - 51
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Publication (45)

PMID Year Title
26092210 2015 RRM1 expression is associated with the outcome of gemcitabine-based treatment of non-small cell lung cancer patients--a short report.
25649960 2015 Expression of sperm-specific protamines impairs bacterial and eukaryotic cell proliferation.
25536093 2015 Quantification of sperm specific mRNA transcripts (PRM1, PRM2, and TNP2) in teratozoospermia and normozoospermia: New correlations between mRNA content and morphology of sperm.
23568457 2013 Genetic variants associated with disordered eating.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
23079002 2012 PRM1 variant rs35576928 (Arg>Ser) is associated with defective spermatogenesis in the Chinese Han population.
22574365 2012 [Association of PRM1-190C- > A polymorphism with teratozoospermia].
22472940 2012 Impact of protamine transcripts and their proteins on the quality and fertilization ability of sperm and the development of preimplantation embryos.
22190364 2011 Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
22104739 2012 Protamine-1 and -2 polymorphisms and gene expression in male infertility: an Italian study.
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