Property Summary

NCBI Gene PubMed Count 309
PubMed Score 572.70
PubTator Score 143.21

Knowledge Summary


No data available


  Differential Expression (3)

Disease log2 FC p
breast carcinoma 1.200 0.037
diabetes mellitus -1.200 0.002
lung carcinoma -2.500 0.000

 GO Function (1)

Gene RIF (301)

26915265 Cellular misfolded proteins rescued from degradation by MHC class II molecules seem to be involved in autoimmune diseases as a target for autoantibodies. (review)
26498496 The observed positive association between integrated HIV-1 DNA load and frequency of CD8(+)DR/DP/DQ(+) cells indicates that a close correlation between HIV persistence and immune activation continues during consistently suppressive therapy.
26462556 Our results further confirm that genetic variants in the HLA-DP locus are strongly associated with reduced HBV infection and increased the likelihood of spontaneous viral clearance.
26449183 Significant associations between chronic hepatitis B infection and five DPB1 alleles (two susceptibility alleles, DPB1(*) 05:01 and (*) 09:01, and three protective alleles, DPB1(*) 02:01, (*) 04:01, and (*) 04:02) were confirmed in Japanese individuals.
26405068 Thyroid autoimmunity is highly prevalent in type 1 diabetes mellitus patients and the risk is modulated by HLA-DRB1 and HLA-DPB1 loci.
26267621 Among recipients of HLA-DPB1-mismatched transplants from donors with the low-expression allele, recipients with the high-expression allele had a high risk of GVHD.
26197724 the HLA-DP/DQ clusters contribute independently to HBV infection, and the 3'-UTR region of HLA-DPB1 represents an important functional region involved in HBV infection
26180102 DQB1*06 and DPB1*13 have roles in modulating vaccine-induced antibody responses to affect HIV-1 acquisition
26031576 findings indicate the HLA-DPB1*13:01 and +550 A alleles are significantly associated with cervical squamous cell carcinoma (CSCC) risk in Taiwanese women; in addition, significant increase in CSCC risk was observed for HLA-DPB1*13:01-G and DPB1*02:01-A haplotypes
26010309 HLA-DPB1*04:01 may reduce the risk of tissue transglutaminase autoantibodies, an early marker of celiac disease, among DR3-DQ2 children, confirming that additional variants in the HLA region influence the risk for celiac disease autoimmunity.

AA Sequence


Text Mined References (332)

PMID Year Title
26915265 2016 [Misfolded proteins complexed with HLA class II molecules are involved in autoimmune diseases as a target for autoantibodies].
26498496 2015 During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ.
26462556 2015 Quantitative assessment of common genetic variations in HLA-DP with hepatitis B virus infection, clearance and hepatocellular carcinoma development.
26449183 2015 Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals.
26405068 2015 Genetics of Autoimmune Thyroiditis in Type 1 Diabetes Reveals a Novel Association With DPB1*0201: Data From the Type 1 Diabetes Genetics Consortium.
26267621 2015 High HLA-DP Expression and Graft-versus-Host Disease.
26197724 2015 Fine mapping analysis of HLA-DP/DQ gene clusters on chromosome 6 reveals multiple susceptibility loci for HBV infection.
26180102 2015 HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition.
26085212 2015 Molecular mechanism and cellular function of MHCII ubiquitination.
26031576 2015 Genetic susceptibility to cervical squamous cell carcinoma is associated with HLA-DPB1 polymorphisms in Taiwanese women.