Property Summary

NCBI Gene PubMed Count 236
Grant Count 241
R01 Count 125
Funding $29,380,307.74
PubMed Score 4499.15
PubTator Score 2345.81

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (9)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.501 0.033
Multiple myeloma 2.044 0.000
glioblastoma 1.100 0.023
primary pancreatic ductal adenocarcinoma 1.300 0.003
non-small cell lung cancer 1.287 0.000
lung cancer 2.400 0.000
pancreatic cancer 1.400 0.002
lung adenocarcinoma 1.083 0.000
ovarian cancer 2.900 0.000

Synonym

Accession P04406 E7EUT4 P00354 Q53X65 GAPDH
Symbols G3PD
GAPD
HEL-S-162eP

Gene

PANTHER Protein Class (2)

PDB

1U8F   1ZNQ   2FEH   3GPD   4WNC   4WNI  

MLP Assay (3)

AID Type Active / Inconclusive / Inactive Description
1227 confirmatory 33 / 148 / 563 GAPDH Dose Response Colorimetric Assay
2472 screening 1950 / 0 / 289495 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen
2795 confirmatory 84 / 135 / 1259 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen confirmation

Gene RIF (131)

PMID Text
26713364 The results of this study led us to conclude that in cancer cells constantly exposed to conditions of oxidative stress, the protective power of Hsp70 should be abolished by specific inhibitors of Hsp70 expression.
26626483 Data revealed that GAPDH is a phosphorylation substrate for AMPK and its interaction with Sirt1 in the nucleus. The phosphorylation and the nuclear translocation of GAPDH mediate rapid Sirt1 activation and autophagy initiation under glucose deprivation.
26564736 This review will summarize our current understanding of GAPDH-mediated regulation of RNA function
26527100 analysis of PSCA level in the peripheral blood of PC patients who underwent radical prostatectomy shows it is related to a GADPH reference level (PSCA/GAPDH ratio)
26438826 findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of diabetic retinopathy
26359500 suggests that GAPDH aggregates accelerate Abeta amyloidogenesis, subsequently leading to mitochondrial dysfunction and neuronal cell death in the pathogenesis of AD
26279122 transient silencing of GAPDH reduces intracellular ROS and facilitates increased autophagy, thereby reducing acute hypoxia and reoxygenation injury as well as the resulting apoptosis and necrosis.
26258539 Genetic variants in GAPDH confer susceptibility to sporadic Parkinson's disease in a Chinese Han population.
26255202 The activity of GAPDS was significantly positively correlated with sperm motility and negatively with the incidence of infertility.
26203648 The level of GAPDH-AP DNA adduct formation depends on oxidation of the protein SH-groups; disulfide bond reduction in GAPDH leads to the loss of its ability to form the adducts with AP DNA
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AA Sequence

MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVIN      1 - 70
GNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKY     71 - 140
DNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPAS    141 - 210
TGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQ    211 - 280
VVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE                   281 - 335
//

Text Mined References (256)

PMID Year Title
26713364 2016 Hsp70 chaperone rescues C6 rat glioblastoma cells from oxidative stress by sequestration of aggregating GAPDH.
26626483 2015 AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation.
26564736 The sweet side of RNA regulation: glyceraldehyde-3-phosphate dehydrogenase as a noncanonical RNA-binding protein.
26527100 2015 The Quantified Level of Circulating Prostate Stem Cell Antigen mRNA relative to GAPDH Level Is a Clinically Significant Indictor for Predicting Biochemical Recurrence in Prostate Cancer Patients after Radical Prostatectomy.
26465922 2016 Altered ?-synuclein, parkin, and synphilin isoform levels in multiple system atrophy brains.
26438826 2015 High Glucose-induced Retinal Pericyte Apoptosis Depends on Association of GAPDH and Siah1.
26359500 2015 Glyceraldehyde-3-phosphate Dehydrogenase Aggregates Accelerate Amyloid-? Amyloidogenesis in Alzheimer Disease.
26279122 2015 GAPDH-silence preserves H9C2 cells from acute hypoxia and reoxygenation injury.
26258539 2015 Genetic variants in GAPDH confer susceptibility to sporadic Parkinson's disease in a Chinese Han population.
26255202 2015 Oxidation of glyceraldehyde-3-phosphate dehydrogenase decreases sperm motility in diabetes mellitus.
More...