Tchem SHBG Sex hormone-binding globulin

Protein Summary

Description

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• P04278
• B0FWH4
• E9PGW1
• F5H5Z8
• I3L1N7
• P14689
• Q16616
• Q3MIL0
• Q6ISD2
• SHBG

Gene Name

• SHBG

Ensembl ID

• ENST00000380450
• ENSP00000369816
• ENSG00000129214
• ENST00000416273
• ENSP00000388867
• ENST00000441599
• ENSP00000393426
• ENST00000575903
• ENSP00000458973

Symbol

• ABP
• SBP
• TEBG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.96
chemical	0.96
cell type or tissue	0.83
drug	0.75
disease	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7138.73   (req: < 5)

Gene RIFs: 294   (req: <= 3)

Antibodies: 652   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7138.73   (req: >= 5)

Gene RIFs: 294   (req: > 3)

Antibodies: 652   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 58

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 31