Property Summary

NCBI Gene PubMed Count 115
PubMed Score 272.62
PubTator Score 193.65

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
lung carcinoma 2844 4.70185274332056E-43
Duchenne muscular dystrophy 602 2.30877766338687E-9
juvenile dermatomyositis 1189 5.54043002733943E-8
lung cancer 4473 2.62506145417202E-7
non-small cell lung cancer 2798 3.97566754540082E-6
ovarian cancer 8492 8.48637563183136E-6
pilocytic astrocytoma 3086 6.3379778650322E-5
active ulcerative colitis 477 1.16250104491001E-4
limb girdle muscular dystrophy 2I 56 3.66289247054854E-4
active Crohn's disease 918 6.41544318621765E-4
Down syndrome 548 9.1587237724226E-4
Becker muscular dystrophy 187 0.00122319974661923
astrocytoma 1493 0.00136605709972146
glioblastoma 5572 0.00136734702035979
Rheumatoid Arthritis 1171 0.0013812082925213
atypical teratoid / rhabdoid tumor 4369 0.00214256781040862
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00242668392007449
invasive ductal carcinoma 2950 0.00248219413128003
psoriasis 6685 0.00381551143045149
pediatric high grade glioma 2712 0.0043926323309156
subependymal giant cell astrocytoma 2287 0.00461937823503841
posterior fossa group A ependymoma 1511 0.00503513670511211
interstitial cystitis 2299 0.016874873635812
esophageal adenocarcinoma 737 0.019009086601478
adrenocortical carcinoma 1427 0.0219201740212073
Breast cancer 3099 0.032842714237338
acute myeloid leukemia 785 0.0412136906670177
osteosarcoma 7933 0.0464130974377841
primary Sjogren syndrome 789 0.0496930003933513
Disease Target Count Z-score Confidence
Cancer 2346 4.209 2.1



Accession P04233 A8K7R1 B4DNE8 D3DQG3 D3DQG4 Q14597 Q29832 Q5U0J8 Q8SNA0 Q8WLP6
Symbols II



1A6A   3PDO   3PGC   3PGD   3QXA   3QXD   4AEN   4AH2   4X5W   1ICF   1IIE   1L3H   1MUJ  

  Ortholog (8)

Species Source
Chimp OMA Inparanoid
Macaque OMA EggNOG Inparanoid
Mouse OMA Inparanoid
Rat OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (101)

27033518 Studies indicate that the invariant chain (CD74) is critical for antigen presentation.
26500140 FOXP1 represents a novel regulator of genes targeted by the class II MHC transactivator CIITA and CD74.
26412712 an inverse correlation with the tumor size for stromal MIF and a positive correlation with the triple receptor negative tumor status for stromal CD74 seem to be showed
26198699 Invariant chain is a new chaperone for TLR7 in B cells. (Review)
26039541 Interferon gamma promotes melanoma cell survival regulating CD74-MIF interaction.
25998395 HIV-1 Nef cloned from subjects with early/acute progressive HIV infection upregulates CD74 (Ii) in 721.221 cells to a greater extent relative to HIV-1 Nef cloned from subjects with chronic progressive infection
25983110 A conserved WW domain-like motif regulates CD74 antigen-dependent cell-surface transport of the NKG2D ligand ULBP2.
25600560 CD74 expression and its therapeutic potential in thyroid carcinoma
25304249 Specific targeting of the CD74 on the lymphoma cell surface will sensitize CD74-expressing cancer cells to Fas-mediated apoptosis.
25175718 The results of this stusy suggested that the CD74 represents a positive prognostic marker most probably because of its association with an M1-polarized immune milieu in high-grade gliomas.

AA Sequence

SSGLGVTKQDLGPVPM                                                          281 - 296

Text Mined References (124)

PMID Year Title
27033518 2016 The multifaceted roles of the invariant chain CD74--More than just a chaperone.
26500140 2016 FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas.
26412712 2015 Macrophage migration inhibitory factor involvement in breast cancer (Review).
26198699 2015 Invariant chain is a new chaperone for TLR7 in B cells.
26039541 2015 Cell Surface CD74-MIF Interactions Drive Melanoma Survival in Response to Interferon-?.
25983110 2015 A conserved WW domain-like motif regulates invariant chain-dependent cell-surface transport of the NKG2D ligand ULBP2.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25600560 2015 CD74 expression and its therapeutic potential in thyroid carcinoma.
25304249 2014 CD74 interferes with the expression of fas receptor on the surface of lymphoma cells.
25241761 2014 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.