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Tchem Proto-oncogene Mas

Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]

 Comments

Property Summary

Ligand Count 2
NCBI Gene PubMed Count 42
PubMed Score 96.91
PubTator Score 42.10

Knowledge Summary

Patent (2,712)

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Thrombosis 46 0.0 0.0
Disease Target Count P-value
ovarian cancer 8520 2.3e-08
osteosarcoma 7950 6.0e-05
medulloblastoma, large-cell 6241 1.1e-04
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Cancer 2499 0.0 4.0

Expression

  Differential Expression (3)

Disease log2 FC p
medulloblastoma, large-cell 1.100 1.1e-04
osteosarcoma 1.061 6.0e-05
ovarian cancer 1.700 2.3e-08

Synonym

Accession P04201 E1P5B3 Q2TBC9 Q6FG47
Symbols MAS
MGRA

Gene

MAS1

  Ortholog (10)

Species Source Disease
OMA EggNOG
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA
OMA EggNOG
Inparanoid OMA
OMA EggNOG
Inparanoid OMA

 Collection (1)

 UniProt Keyword (11)

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 GO Function (5)

 GO Component (4)

 GO Process (16)

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 Compartment GO Term (13)

 IMPC Phenotype (1)

 MGI Phenotype (5)

 HCA RNA Cell Line (55)

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Pathway (4)

Protein-protein Interaction (64)

ACAD10   BTAF1   GCN1   TUBGCP2   POTEF   ACTA2   NCAPD2   INTS12   FASTKD1   ITPRIP   SLC30A5   ARL10   PDS5B   IDH2   VMP1   ERBB2   PDS5A   TYK2   JAK1   ASPRV1   TBRG4   KIRREL1   ATP6V1H   ZYX   RELT   SPG7   ECPAS   EPHA2   ATM   BMPR1A   SLC7A6   SELENBP1   FLT4   ACVR2B   CRYAB   SFXN5   MTX1   ABHD17B   XPO7   ABHD3   EARS2   TTK   PKP3   RAB3B   NCAPG   ATP13A3   DUSP14   ARL8B   GPR50   ATL3   ATL2   METTL15   DSG4   RETREG3   TMEM11   SLC35G2   ZFPL1   ABCD1   SLC4A7   EFHD1   ATAD1   SGPP1   FAM241B   PKN3  

Ligand (2)

Structure of AVE 0991

AVE 0991
pIC50 7.32

Structure of AR244555

AR244555
pIC50 6.46

Gene RIF (22)

AA Sequence 

MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMRRNPFTVYI      1 - 70
THLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWY     71 - 140
RCHRPKYQSALVCALLWALSCLVTTMEYVMCIDREEESHSRNDCRAVIIFIAILSFLVFTPLMLVSSTIL    141 - 210
VVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYWSTFGNLHHISLLFSTINSSANPFIY    211 - 280
FFVGSSKKKRFKESLKVVLTRAFKDEMQPRRQKDNCNTVTVETVV                             281 - 325
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Text Mined References (43)

PMID Year Title