| Tchem | Proto-oncogene Mas |
Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]
Comments
Property Summary
| NCBI Gene PubMed Count | 39 |
| Grant Count | 32 |
| R01 Count | 15 |
| Funding | $4,854,432.34 |
| PubMed Score | 92.51 |
| PubTator Score | 42.10 |
| Disease | Z-score | Confidence |
|---|---|---|
| Cancer 2,346 | 4.0 | |
| medulloblastoma, large-cell 6,234 | ||
| osteosarcoma 7,933 | ||
| ovarian cancer 8,484 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | 1.061 | 0.000 |
| medulloblastoma, large-cell | 1.100 | 0.000 |
| ovarian cancer | 1.700 | 0.000 |
| PMID | Text |
|---|---|
| 26225830 | Ang-(1-7) downregulated AT1R mRNA, upregulated mRNA levels of Ang II type 2 receptor (AT2R) and Mas receptor (MasR) and p38-MAPK phosphorylation and suppressed H22 cell-endothelial cell communication |
| 26080617 | MAS1 might act as an inhibitory regulator of breast cancer. |
| 25068582 | Data show that MAS receptor exhibited constitutive activity that was inhibited by the non-peptide inverse agonist. |
| 24168260 | Up-regulation of the ACE2/Ang-(1-7)/Mas axis protected against pulmonary fibrosis by inhibiting the MAPK/NF-kappaB pathway. |
| 24128372 | A proximal promoter construct for the MAS gene was repressed by the SOX [SRY (sex-determining region on the Y chromosome) box] proteins SRY, SOX2, SOX3 and SOX14, of which SRY is known to interact with the KRAB domain. |
| 23592774 | Control of adipogenesis by the autocrine interplays between angiotensin 1-7/Mas receptor and angiotensin II/AT1 receptor signaling pathways. |
| 23488800 | Data suggest that angiotensin converting enzyme 2/angiotensin II-(1-7)/MAS1 axis regulates leukocyte recruitment/activation, cell proliferation, and inflammation/fibrosis; main topic here is kidney/inflammatory renal disease. [REVIEW] |
| 23459756 | Mas appears to be a critical component required for NO-mediated vasodilatation induced by renin angiotensin system-dependent and RAS-independent agonists and therefore arises as a key pharmacological target to modulate endothelial function |
| 22048948 | MasR was significantly upregulated in colon adenocarcinoma compared with non-neoplastic colon mucosa, which showed little or no expression of it. ACE gene expression and enzymatic activity were also increased in the tumors. |
| 22003054 | Activation of Mas during myocardial infarction contributes to ischemia-reperfusion injury and suggest that inhibition of Mas-G(q) signaling may provide a new therapeutic strategy directed at cardioprotection. |
| More... |
MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMRRNPFTVYI 1 - 70 THLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWY 71 - 140 RCHRPKYQSALVCALLWALSCLVTTMEYVMCIDREEESHSRNDCRAVIIFIAILSFLVFTPLMLVSSTIL 141 - 210 VVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYWSTFGNLHHISLLFSTINSSANPFIY 211 - 280 FFVGSSKKKRFKESLKVVLTRAFKDEMQPRRQKDNCNTVTVETVV 281 - 325 //
| PMID | Year | Title |
|---|---|---|
| 26460884 | 2015 | G protein-coupled receptors directly bind filamin A with high affinity and promote filamin phosphorylation. |
| 26225830 | 2015 | Angiotensin-(1-7) Suppresses Hepatocellular Carcinoma Growth and Angiogenesis via Complex Interactions of Angiotensin II Type 1 Receptor, Angiotensin II Type 2 Receptor and Mas Receptor. |
| 26080617 | 2015 | Expression of MAS1 in breast cancer. |
| 25068582 | 2014 | Atypical signaling and functional desensitization response of MAS receptor to peptide ligands. |
| 24583173 | 2014 | Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. |
| 24168260 | 2014 | Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis protects against lung fibrosis by inhibiting the MAPK/NF-?B pathway. |
| 24128372 | 2014 | MAS promoter regulation: a role for Sry and tyrosine nitration of the KRAB domain of ZNF274 as a feedback mechanism. |
| 23592774 | 2013 | Control of adipogenesis by the autocrine interplays between angiotensin 1-7/Mas receptor and angiotensin II/AT1 receptor signaling pathways. |
| 23488800 | 2013 | ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis. |
| 23459756 | 2013 | Complete blockade of the vasorelaxant effects of angiotensin-(1-7) and bradykinin in murine microvessels by antagonists of the receptor Mas. |
| More... |
