Property Summary

NCBI Gene PubMed Count 129
PubMed Score 254.86
PubTator Score 353.62

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
colon cancer 1475 3.00632956661329E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00165539291190062
lung adenocarcinoma 2714 0.00332195038422669
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00435205205833883
severe asthma 11 0.00486541012638661
breast carcinoma 1614 0.00540360981437028
fibroadenoma 557 0.0144266738017088
interstitial cystitis 2299 0.0146259658521981
esophageal adenocarcinoma 737 0.0176010007179145
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0202055657533297
Barrett's esophagus 185 0.0248140872226793
Breast cancer 3099 0.0295578435629019
active ulcerative colitis 477 0.0393076800310566
Disease Target Count Z-score Confidence
pancreatic cancer 2300 0.0 2.0
Disease Target Count Z-score Confidence
Cancer 2346 4.619 2.3
Gastritis 44 3.326 1.7



Accession P04155
Symbols pS2


PANTHER Protein Class (2)


1HI7   1PS2  

  Ortholog (7)

Gene RIF (100)

26617749 we found TFF1 plays an oncogenic role in mucinous ovarian cancer
26390128 These results show increased levels of TFF1 and TFF3 in Chronic Kidney Disease patients with a pronounced elevation of urinary TFF1 in lower Chronic Kidney Disease stages.
26372254 Findings underscore an important protective role of TFF1 in abrogating H. pylori-mediated inflammation, a crucial hallmark of gastric tumorigenesis. Loss of TFF1 expression could be an important step in H. pylori-mediated gastric carcinogenesis.
26276775 trefoil factor 1 demonstrated breast specificity but was inferior to mammaglobin and GATA protein binding 3
26240479 These findings suggest that the rs184432 and rs225359 polymorphisms in TFF1 have protective effects for GC and contribute to the development of GC in Korean individuals.
26240291 We have established a novel, three-protein biomarker panel that is able to detect patients with early-stage pancreatic cancer in urine specimens:LYVE-1, REG1A, and TFF1 were selected as candidate biomarkers
25990322 This study provides a potent tool of rTFF1 production to be applied in gastric damage protection and wound healing. The protein sources from B. choshinensis were more efficient than rTFF1 produced by E. coli
25980439 Loss of TFF1 could be a critical step in promoting the H. pylori-mediated oncogenic activation of beta-catenin and gastric tumorigenesis.
25652124 Data indicate that microRNA miR218-5p negatively regulates trefoil factor 1 (TFF1) in an extracellular signal-regulated kinases Erk1/2-dependent manner.
25486181 Trefoil Factor 1 levels can influence copper excretion and copper related toxicity.

AA Sequence

PNTIDVPPEEECEF                                                             71 - 84

Text Mined References (131)

PMID Year Title
26617749 2015 Trefoil factor 1 elevates the malignant phenotype of mucinous ovarian cancer cell through Wnt/?-catenin signaling.
26390128 2015 Trefoil Factor 1 Excretion Is Increased in Early Stages of Chronic Kidney Disease.
26372254 2015 Trefoil factor 1 expression suppresses Helicobacter pylori-induced inflammation in gastric carcinogenesis.
26276775 2015 Evaluating the utility of trefoil factor 1 as a mammary-specific immunostain compared and in conjunction with GATA-3 and mammaglobin in the distinction between carcinoma of breast and lung.
26240479 2015 Association between Promoter Polymorphisms of TFF1, TFF2, and TFF3 and the Risk of Gastric and Diffuse Gastric Cancers in a Korean Population.
26240291 2015 Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma.
25990322 2015 Functional expression of recombinant human trefoil factor 1 by Escherichia coli and Brevibacillus choshinensis.
25980439 2015 Loss of TFF1 promotes Helicobacter pylori-induced ?-catenin activation and gastric tumorigenesis.
25652124 2015 miR218-5p regulates the proliferation of gastric cancer cells by targeting TFF1 in an Erk1/2-dependent manner.
25486181 2015 Trefoil Factor 1 is involved in gastric cell copper homeostasis.