Property Summary

NCBI Gene PubMed Count 842
Grant Count 1,475
R01 Count 855
Funding $226,419,083.08
PubMed Score 2131.29
PubTator Score 3774.46

Knowledge Summary

Patent (124,718)

TINX Plot

  Disease Relevance (217)

Disease Z-score Confidence
Cushing's syndrome 47 5.337 2.7
post-traumatic stress disorder 45 4.942 2.5
Asthma 349 4.93 2.5
Cancer 2,346 4.471 2.2
Major Depressive Disorder 106 4.257 2.1
Obesity 616 4.161 2.1
Metabolic syndrome X 155 3.981 2.0
Kidney disease 396 3.932 2.0
Hypertension 287 3.869 1.9
diabetes mellitus 1,663 3.793 1.9
Pituitary adenoma 35 3.472 1.7
Bipolar Disorder 266 3.411 1.7
Chronic obstructive pulmonary disease 146 3.283 1.6
Chronic fatigue syndrome 29 3.242 1.6
Hyperandrogenism 32 3.111 1.6
Hyperglycemia 120 3.041 1.5
Hypokalemia 40 3.038 1.5
46, XX Disorders of Sex Development 1
Acne vulgaris 16
Acquired thrombocytopenia 7
Acute lymphoid leukemia 25
Adrenal cortical hypofunction 7
Adrenogenital disorder 6
Allergic Rhinitis Prevention 1
Allergic asthma 6
Allergic bronchopulmonary aspergillosis 4
Allergic conjunctivitis 25
Allergic otitis externa 1
Allergic rhinitis 91
Alopecia areata 37
Angioedema 36
Ankylosing spondylitis 138
Anterior uveitis 3
Aphthous ulcer of mouth 7
Articular gout 11
Aspiration pneumonitis 6
Asthma management 20
Atopic dermatitis 944
Autoimmune disease 5
Autoimmune hemolytic anemia 17
Bacterial conjunctivitis 10
Bacterial keratitis 5
Berylliosis 16
Blepharoconjunctivitis 5
Branch retinal vein occlusion with macul... 4 
Breast cancer 3,094
Bronchospasm Prevention with COPD 3
Burkitt's lymphoma 15
Bursitis 10
COPD Associated with Chronic Bronchitis 11
Candidiasis of skin 6
Central retinal vein occlusion with macu... 4 
Cerebral edema 5
Chloasma 5
Choroiditis 5
Chronic Non-Allergic Rhinitis 1
Chronic lymphoid leukemia, disease 10
Chronic ulcerative proctitis 7
Cocaine-Related Disorders 88
Congenital adrenal hyperplasia 74
Congenital hypoplastic anemia 8
Contact Dermatitis 80
Corneal abrasion 6
Corneal ulcer 9
Crohn's disease 304
Crohn's disease in remission 1
Cyclitis 6
Cystic Aponeurosis Tumor 1
Dacryocystitis 7
Depressive disorder 48
Dermatitis herpetiformis 11
Dermatosis of scalp 1
Diagnostic Test for Cushing's Syndrome 5
Diffuse Proliferative Lupus Nephritis 1
Diffuse non-Hodgkin's lymphoma, large ce... 12 
Discoid lupus erythematosus 7
Disorder of eye 7
Disorder of musculoskeletal system 5
Disorder of skin 5
Eczema 3
Edema of larynx 5
Endometriosis 535
Eosinophilic asthma 5
Epicondylitis 19
Eruption of skin 5
Erythema multiforme 15
Erythroblastic Anemia 5
Erythroderma 5
Exacerbation of asthma 11
Exfoliative Erythroderma 1
Extrinsic allergic alveolitis 6
Fibrosis of lung 4
Follicular non-Hodgkin's lymphoma 17
Giant cell arteritis 5
Gingival Disorders 3
Glucocorticoid Receptor Deficiency 1
Granuloma annulare 5
Hemorrhoids 13
Herpes zoster keratitis 6
Herpes zoster keratoconjunctivitis 1
Hodgkin's disease 18
Humoral hypercalcemia of malignancy 6
Hypertensive disease 193
Idiopathic thrombocytopenic purpura 5
Infection by larvae of Trichinella spira... 3 
Infective blepharitis 5
Infective otitis externa 4
Infective otitis media 3
Inflammatory bowel disease 142
Inflammatory dermatosis 38
Iridocyclitis 12
Iritis 9
Itching of ear 3
Juvenile rheumatoid arthritis 104
Keloid scar 1
Keratitis 42
Lichen planus 17
Lichen simplex chronicus 7
Lung Diseases, Obstructive 3
Löffler's syndrome 5
Malignant otitis externa due to Pseudomo... 4 
Mastoidectomy Cavity Infections 3
Meibomianitis 4
Miliary tuberculosis 5
Minor Bacterial Skin Infections 3
Multiple Sclerosis 498
Multiple myeloma 1,327
Mycosis fungoides 28
Nasal polyp 2
Necrobiosis lipoidica diabeticorum 1
Nephrotic Syndrome 48
Non-Hodgkin's lymphoma 22
Non-allergic asthma 5
Non-infectious Posterior Uveitis 1
Nummular eczema 1
Ocular hypertension 27
Ocular rosacea 4
Otitis Externa Eczema 1
Otitis Externa Seborrhea 1
Otitis externa 9
Pemphigus 18
Perennial allergic rhinitis 2
Perforation of cornea 1
Pityriasis simplex 6
Plaque psoriasis 14
Pneumocystosis jiroveci pneumonia 7
Polymyalgia rheumatica 10
Post traumatic osteoarthritis 5
Post-Op Ocular Inflammation 10
Postoperative Ocular Pain 5
Pregnancy with abortive outcome 12
Prevention of Transplant Rejection 6
Primary adrenocortical insufficiency 6
Primary cutaneous T-cell lymphoma 24
Proctitis 11
Progressive Diffuse Large B-Cell Lymphom... 4 
Prostatic Neoplasms 471
Pruritus ani 14
Pruritus of genital organs 5
Pseudohermaphroditism 16 4.0
Pseudohermaphroditism, Female, With Hypo... 1 
Psoriasis with arthropathy 11
Psychotic Disorders 20
Pulmonary emphysema 34
Punctate Epithelial Keratopathy 6
Punctate keratitis 1
Punctate keratopathy 3
Recurrent herpes simplex labialis 3
Rheumatic heart disease 8
Rheumatoid Arthritis 1,160
Rhinitis 46
Rosacea 18
Scalp psoriasis 6
Schizophrenia 501
Seasonal allergic rhinitis 10
Seborrheic dermatitis 19
Severe Ocular Inflammation 4
Severe adrenal insufficiency 5
Sjögren's syndrome 5
Staphylococcus Aureus Otitis Externa 4
Stevens-Johnson syndrome 78
Subacute bursitis 1
Superficial Ocular Infection 6
Sympathetic uveitis 4
Synovitis 38
Synovitis due to Osteoarthritis 5
Systemic Dermatomyositis 5
Tendinitis 13
Tenosynovitis 15
Thyroiditis 25
Tinea corporis 25
Tinea cruris 12
Tinea pedis 30
Transfusion Reaction Urticaria 5
Transfusion reaction due to serum protei... 5 
Transplanted organ rejection 10
Tuberculosis Meningitis Treatment Adjunc... 1 
Uveitis 103
Vasomotor rhinitis 15
Vitrectomy Adjunct to Enhance Visualizat... 1 
active ulcerative colitis 477
atypical teratoid / rhabdoid tumor 4,369
breast carcinoma 1,614
ductal carcinoma in situ 1,745
group 4 medulloblastoma 1,875
intraductal papillary-mucinous carcinoma... 2,988 
invasive ductal carcinoma 2,950
lung cancer 4,466
medulloblastoma, large-cell 6,234
osteosarcoma 7,933
ovarian cancer 8,484
primitive neuroectodermal tumor 3,031
psoriasis 6,685
sarcoidosis 358
systemic lupus erythematosus 156
tuberculosis 1,557
ulcerative colitis 2,087

Expression

  Differential Expression (16)

Disease log2 FC p
Multiple myeloma 1.274 0.008
psoriasis -1.100 0.000
osteosarcoma 1.902 0.000
group 4 medulloblastoma -2.400 0.000
atypical teratoid / rhabdoid tumor -1.800 0.001
medulloblastoma, large-cell -2.200 0.001
primitive neuroectodermal tumor -1.400 0.044
tuberculosis -1.700 0.000
intraductal papillary-mucinous carcinoma... -2.700 0.018
lung cancer -2.500 0.000
active ulcerative colitis -1.267 0.033
breast carcinoma -1.800 0.000
Breast cancer -2.000 0.000
ductal carcinoma in situ -1.700 0.000
invasive ductal carcinoma -2.300 0.000
ovarian cancer -2.300 0.000

Synonym

Accession P04150 A0ZXF9 B0LPG8 D3DQF4 F5ATB7 P04151 Q53EP5 Q6N0A4 GR
Symbols GR
GCR
GRL
GCCR
GCRST

Gene

PDB

3H52   4MDD   1M2Z   1P93   3CLD   3E7C   3K22   3K23   4CSJ   4P6W   4P6X   4UDC   4UDD   1NHZ   3BQD   4HN5   4HN6   4LSJ   5CBX   5CBY   5CBZ   5CC1   5EMC   5EMP   5EMQ  

  TechDev Info (1)

Jun Qin Signaling network evaluation of transcript factor crosstalk via catTRE/MS