Tdark PRB2 Basic salivary proline-rich protein 2

Protein Summary

Description

This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats, polymorphic cleavage sites and polymorphic stop codons have been identified. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P02812
• O00599
• P02811
• P04281
• Salivary proline-rich protein

Gene Name

• PRB2

Ensembl ID

• ENST00000389362
• ENSP00000374013
• ENSG00000121335

Symbol

• Ps
• cP7
• IB-9
• PRPPRB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.72
cellular component	0.46
protein complex	0.4
tissue	0.37
disease	0.36

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.73   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 16   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.73   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0