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Tbio
PRH1
Salivary acidic proline-rich phosphoprotein 1/2

Protein Summary
Description
PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth. This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. Multiple distinct alleles of this locus including the parotid isoelectric-focusing variant slow (PIF-s), the parotid acidic protein (Pa), and the double band slow (Db-s) isoforms have been characterized. The reference genome encodes the Db-s allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Co-transcription of this gene with adjacent genes has been observed. Alternate splicing of this gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381847
  • ENSP00000371271
  • ENSG00000134551
  • ENST00000396400
  • ENSP00000379682
  • ENST00000572141
  • ENSP00000458690
  • ENSG00000272803
  • ENST00000575657
  • ENSP00000461041
  • ENST00000622570
  • ENSP00000481810
  • ENSG00000275679
  • ENST00000622848
  • ENSP00000483458

Symbol
  • PA
  • Db-s
  • PRH2
  • PIF-S
  • Pr1/Pr2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.67
cell type or tissue
0.61
cell line
0.6
microRNA
0.49
protein complex
0.42


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 349.08   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 349.08   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0