Tbio TF Serotransferrin

Protein Summary

Description

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P02787
• O43890
• Q1HBA5
• Q9NQB8
• Q9UHV0
• Transferrin

Gene Name

• TF

Ensembl ID

• ENST00000402696
• ENSP00000385834
• ENSG00000091513

Symbol

• TFQTL1
• PRO1557
• PRO2086
• HEL-S-71p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.99
chemical	0.93
interacting protein	0.93
disease	0.91
gene perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Serotransferrin

Protein / Receptor / Serotransferrin

Protein / ... / Serine Protease / Serotransferrin

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Serotransferrin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 464.07   (req: < 5)

Gene RIFs: 249   (req: <= 3)

Antibodies: 1536   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 464.07   (req: >= 5)

Gene RIFs: 249   (req: > 3)

Antibodies: 1536   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0