Tclin TTR Transthyretin

Protein Summary

Description

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P02766
• Q549C7
• Q6IB96
• Q9UBZ6
• Q9UCM9

Gene Name

• TTR

Ensembl ID

• ENST00000237014
• ENSP00000237014
• ENSG00000118271
• ENST00000649620
• ENSP00000497927

Symbol

• PALB
• CTS
• ATTR
• CTS1
• PALB
• TBPA
• HEL111
• HsT2651

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
drug	1
gene perturbation	1
disease perturbation	0.83
chemical	0.82

Protein Classes

PANTHER Classes

Protein / Transporter / Transthyretin

Protein / Transfer/carrier Protein / Transthyretin

DTO Classes

Protein / Transporter / Transthyretin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10739.42   (req: < 5)

Gene RIFs: 465   (req: <= 3)

Antibodies: 1095   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10739.42   (req: >= 5)

Gene RIFs: 465   (req: > 3)

Antibodies: 1095   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11