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Tbio
SLC4A1
Band 3 anion transport protein

Protein Summary
Description
Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262418
  • ENSP00000262418
  • ENSG00000004939

Symbol
  • AE1
  • DI
  • EPB3
  • DI
  • FR
  • SW
  • WD
  • WR
  • AE1
  • CHC
  • SAO
  • WD1
  • BND3
  • EPB3
  • SPH4
  • CD233
  • EMPB3
  • RTA1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
protein domain
0.92
molecular function
0.86
disease perturbation
0.74
kinase
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.3   (req: < 5)
Gene RIFs: 198   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.3   (req: >= 5)
Gene RIFs: 198   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0