Tbio APOA2 Apolipoprotein A-II

Protein Summary

Description

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P02652
• B2R524
• Apo-AII

Gene Name

• APOA2

Ensembl ID

• ENST00000367990
• ENSP00000356969
• ENSG00000158874

Symbol

• apoAII
• Apo-AII
• ApoA-II

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.99
disease perturbation	0.87
biological term	0.72
disease	0.65

Protein Classes

PANTHER Classes

Protein / Transporter / Apolipoprotein A-ii

Protein / Transfer/carrier Protein / Apolipoprotein / Apolipoprotein A-ii

DTO Classes

Protein / Transporter / Apolipoprotein / Apolipoprotein A-ii

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 788.71   (req: < 5)

Gene RIFs: 92   (req: <= 3)

Antibodies: 476   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 788.71   (req: >= 5)

Gene RIFs: 92   (req: > 3)

Antibodies: 476   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0