| Tbio | Troponin C, skeletal muscle |
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]
Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 7.1e-35 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.4e-06 |
| glioblastoma | 5792 | 9.1e-06 |
| primitive neuroectodermal tumor | 3035 | 2.3e-04 |
| oligodendroglioma | 2850 | 3.1e-03 |
| astrocytic glioma | 2597 | 6.4e-03 |
| ependymoma | 4679 | 6.7e-03 |
| diabetes mellitus | 1728 | 3.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.200 | 6.4e-03 |
| atypical teratoid / rhabdoid tumor | -1.100 | 2.4e-06 |
| diabetes mellitus | -1.500 | 3.6e-02 |
| ependymoma | -1.200 | 6.7e-03 |
| glioblastoma | -1.100 | 9.1e-06 |
| oligodendroglioma | -1.300 | 3.1e-03 |
| primitive neuroectodermal tumor | -1.100 | 2.3e-04 |
| psoriasis | -1.300 | 7.1e-35 |
