Tchem | Troponin C, skeletal muscle |
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]
Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | P-value |
---|---|---|
psoriasis | 6685 | 7.09314465522323E-35 |
atypical teratoid / rhabdoid tumor | 4369 | 2.36651659591557E-6 |
glioblastoma | 5572 | 9.12371500779703E-6 |
primitive neuroectodermal tumor | 3031 | 2.32126927259681E-4 |
oligodendroglioma | 2849 | 0.00308967017219373 |
astrocytic glioma | 2241 | 0.00644922246423719 |
ependymoma | 2514 | 0.00668496026453967 |
diabetes mellitus | 1663 | 0.0362082534487051 |
Disease | log2 FC | p |
---|---|---|
astrocytic glioma | -1.200 | 0.006 |
ependymoma | -1.200 | 0.007 |
oligodendroglioma | -1.300 | 0.003 |
atypical teratoid / rhabdoid tumor | -1.100 | 0.000 |
glioblastoma | -1.100 | 0.000 |
primitive neuroectodermal tumor | -1.100 | 0.000 |
diabetes mellitus | -1.500 | 0.036 |
psoriasis | -1.300 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG |
Pig | OMA EggNOG Inparanoid |
Opossum | EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
Zebrafish | OMA Inparanoid |
PMID | Text |
---|---|
20628086 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
19913121 | Observational study of gene-disease association. (HuGE Navigator) |
19460752 | Knockdown of troponin C type 2 (TNNC2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells |
1907279 | HIV-1 protease hydrolyzes troponin C at amino acid residues 101-102 |
PMID | Year | Title |
---|---|---|
25416956 | 2014 | A proteome-scale map of the human interactome network. |
20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |
19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. |
17194691 | 2007 | Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
11780052 | 2001 | The DNA sequence and comparative analysis of human chromosome 20. |
9560191 | 1998 | Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution. |
9459007 | 1997 | Assignment of the human fast skeletal muscle troponin C gene (TNNC2) between D20S721 and GCT10F11 on chromosome 20 by somatic cell hybrid analysis. |
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