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  6. Troponin C, skeletal muscle

Tbio Troponin C, skeletal muscle

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 15
PubMed Score 6.68
PubTator Score 9.08

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Distal arthrogryposis 42 4.461 2.2
Clubfoot 39 3.504 1.8
Spondylolisthesis 22 3.489 1.7

Expression

  Differential Expression (8)

Disease log2 FC p
astrocytic glioma -1.200 6.4e-03
atypical teratoid / rhabdoid tumor -1.100 2.4e-06
diabetes mellitus -1.500 3.6e-02
ependymoma -1.200 6.7e-03
glioblastoma -1.100 9.1e-06
oligodendroglioma -1.300 3.1e-03
primitive neuroectodermal tumor -1.100 2.3e-04
psoriasis -1.300 7.1e-35

Synonym

Accession P02585 Q6FH92
Symbols

Gene

TNNC2

PANTHER Protein Class (3)

  Ortholog (12)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (8)

 GO Function (3)

 GO Component (2)

 GO Process (3)

 Compartment GO Term (32)

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 HCA RNA Cell Line (50)

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Pathway (53)

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Protein-protein Interaction (32)

UBB   ACTA2   CALML3   SPECC1L   CHAMP1   NRIP1   ITPR2   ITPR3   KIF20A   ZNF74   DCAF6   MAGED2   ECI2   IQGAP1   CLSPN   PML   MAML1   SSFA2   MAP7D3   MTPAP   SMARCD3   ATF7IP   ZBTB21   POGZ   SEPHS2   HIRIP3   ARNT   RPS6KA4   PAX6   TNNI2   TNNI1   TNNI3  

Gene RIF (4)

AA Sequence 

MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGT      1 - 70
IDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIFRASGEHVTDEEIESLMKDGD     71 - 140
KNNDGRIDFDEFLKMMEGVQ                                                      141 - 160
//

Text Mined References (16)

PMID Year Title