Property Summary

NCBI Gene PubMed Count 265
PubMed Score 179.80
PubTator Score 203.60

Knowledge Summary


No data available


  Disease Sources (7)

Disease Target Count P-value
lung adenocarcinoma 2714 3.09168516059004E-21
non-small cell lung carcinoma 413 1.32248925515038E-17
cystic fibrosis 1670 1.69349896032457E-8
astrocytoma 1493 4.39547707530162E-8
ovarian cancer 8492 4.19860009839032E-6
intraductal papillary-mucinous carcinoma (IPMC) 2988 5.42966263556979E-6
breast carcinoma 1614 1.20253918207338E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 1.95955398995907E-5
invasive ductal carcinoma 2950 2.61697710503621E-5
lung cancer 4473 4.18039953968447E-5
psoriasis 6685 4.81431373599689E-5
pituitary cancer 1972 6.92145473205931E-5
colon cancer 1475 3.09209753322787E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 3.35697807046937E-4
Atopic dermatitis 944 4.62333082115276E-4
non-inflammatory breast cancer 208 0.00101209514590974
Down syndrome 548 0.00111016610708048
atypical teratoid/rhabdoid tumor 1095 0.00153546960166262
ductal carcinoma in situ 1745 0.0019907310922018
fibroadenoma 557 0.00373188709000882
medulloblastoma, large-cell 6234 0.00443924704208993
sonic hedgehog group medulloblastoma 1482 0.0110239168326627
Endometriosis 535 0.0211860661516895
esophageal adenocarcinoma 737 0.023355895271404
Barrett's esophagus 185 0.0342824727724281
Disease Target Count Z-score Confidence
Dilated cardiomyopathy 51 0.0 5.0
Disease Target Count Z-score Confidence
Cataract 104 4.549 2.3
Cardiomyopathy 110 4.189 2.1
Myopathy 128 3.723 1.9
Disease Target Count Z-score Confidence
Pearson syndrome 17 3.742 1.9
Multiple Sclerosis 498 3.23 1.6


  Differential Expression (25)


Accession P02511 B0YIX0 O43416 Q9UC37 Q9UC38 Q9UC39 Q9UC40 Q9UC41
Symbols MFM2


PANTHER Protein Class (1)


2KLR   2N0K   2WJ7   2Y1Y   2Y1Z   2Y22   2YGD   3J07   3L1G   3SGM   3SGN   3SGO   3SGP   3SGR   3SGS   4M5S   4M5T  

  Ortholog (12)

Gene RIF (219)

27129211 Alpha B-crystalline plays an important regulatory role in exosome biogenesis.
26878210 alphaB-crystallin is an important regulator of epithelial-mesenchymal transition, acting as a molecular chaperone for SMAD4 and as its potential therapeutic target for preventing subretinal fibrosis development in neovascular age-related macular degeneration
26657544 Similar to wild type alphaA- and alphaB-crystallins, the deamidated mutants showed strong interaction with betaA3-crystallin.
26620801 Data show that phosphorylation of crystallin alphaB (cryAB) deters its packaging into vesicles for exosomal secretion.
26464626 alpha B crystallin is an independent prognostic factor of infiltrating ductal carcinoma of the breast
26458046 These data suggest that alphaB-crystallin uses its inherent structural plasticity to expose distinct binding interfaces and thus interact with a wide range of structurally variable clients.
26415747 Phosphorylation of alphaB-crystallin has dual role that manifests either beneficial or deleterious consequences depending on the extent of phosphorylation and interaction with cytoskeleton. [review]
26402864 two novel missense mutations, p.R11C and p.R12C, in CRYAB associated with autosomal recessive congenital nuclear cataracts.
26351848 In the lens epithelium of the high myopia-related cataract group and the age related cataract group, the mRNA and soluble protein expression of aA- and aB-crystallin were both decreased.
26341790 The multifunctional activity of human alphaB crystallin results from the interactive peptide sequences exposed on the surface of the molecule. [review]

AA Sequence

GVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK                                       141 - 175

Text Mined References (271)

PMID Year Title
27129211 2016 Inhibition of the Expression of the Small Heat Shock Protein ?B-Crystallin Inhibits Exosome Secretion in Human Retinal Pigment Epithelial Cells in Culture.
26878210 2016 ?B-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition.
26657544 2015 Interaction of ?A3-Crystallin with Deamidated Mutants of ?A- and ?B-Crystallins.
26620801 2016 Phosphorylation negatively regulates exosome mediated secretion of cryAB in glioma cells.
26464626 2015 Expression of alpha B crystallin and BCL2 in patients with infiltrating ductal carcinoma.
26458046 2015 The chaperone ?B-crystallin uses different interfaces to capture an amorphous and an amyloid client.
26415747 2016 Phosphorylation of ?B-crystallin: Role in stress, aging and patho-physiological conditions.
26402864 2015 Missense Mutations in CRYAB Are Liable for Recessive Congenital Cataracts.
26351848 2015 UPR Activation and the Down-Regulation of ?-Crystallin in Human High Myopia-Related Cataract Lens Epithelium.
26341790 2016 Functional sequences in human alphaB crystallin.