Property Summary

NCBI Gene PubMed Count 1,337
PubMed Score 256.47
PubTator Score 486.31

Knowledge Summary


No data available


  Disease Sources (5)

Disease Target Count P-value
lung carcinoma 2844 6.02990746865769E-11
non-small cell lung cancer 2798 1.34876151180902E-8
Duchenne muscular dystrophy 602 1.71547515548852E-8
ovarian cancer 8492 6.39781474704589E-6
lung cancer 4473 1.62975453077645E-5
juvenile dermatomyositis 1189 8.36123498368063E-5
cystic fibrosis 1670 1.05240146960993E-4
active ulcerative colitis 477 3.3173445269301E-4
primary Sjogren syndrome 789 4.45058942432912E-4
active Crohn's disease 918 7.73558218545843E-4
pancreatic carcinoma 567 0.00111224603653342
limb girdle muscular dystrophy 2I 56 0.00125985754840536
glioblastoma 5572 0.00140208817307648
interstitial cystitis 2299 0.00149866050212336
atypical teratoid/rhabdoid tumor 1095 0.00154551743613612
pilocytic astrocytoma 3086 0.00231017537497964
medulloblastoma, large-cell 6234 0.00274590222492973
nephrosclerosis 329 0.00378338045728314
pancreatic cancer 2300 0.00539852923527975
breast carcinoma 1614 0.00881763130879464
astrocytoma 1493 0.00915912120236905
group 4 medulloblastoma 1875 0.0132486705057651
tuberculosis 1563 0.0140216946144813
primary pancreatic ductal adenocarcinoma 1271 0.0140647950629297
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0172785052365641
subependymal giant cell astrocytoma 2287 0.0185754893820071
esophageal adenocarcinoma 737 0.0191380706156918
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0193300328049592
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.019971344214076
type I diabetes mellitus 22 0.0215985070264956
ductal carcinoma in situ 1745 0.0256097394674998
colon cancer 1475 0.0279537122473758
pituitary cancer 1972 0.0375616160762838
invasive ductal carcinoma 2950 0.0397775568332958
Waldenstrons macroglobulinemia 765 0.0473839743328283


Gene RIF (1428)

27049564 This study findings indicate a possibly increased prevalence of neuromyelitis optica in Muslim Arabs in Israel with distinct (positive and negative) HLA associations.
26829741 HLA-DQB1*03:03 allele is predisposing factor for unexplained recurrent spontaneous abortion.
26818121 HLA-DQA1*0102 and HLA-DQB1*0201 alleles may be involved in the production of anti-beta2-glycoprotein I antibody in recurrent miscarriage patients.
26744784 The results of this study confirm that HLA-DQB1 alleles, genotypes and haplotypes are associated with MS risk in the Slovak population.
26681219 HLA-DQB1*0325 and HLA-DQB1*0332 probably act as cervical cancer susceptibility genes in Uyghur women from Xinjiang; HLA-DQB1*0317 and HLA-DQB1*040302 may be protective genes
26671138 DRB1*04 (DR4) (41/214 vs 42/400, Pc = 0.042, OR = 2.02, 95% CI 1.27-3.22) and DQB1*0302 (35/214 vs 32/400, Pc = 0.014, OR = 2.25, 95% CI 1.35-3.75) had significant positive association with AChR MG compared to controls, and
26476208 genetic polymorphism influences the clinical course of red blood cells transfusion in patients with sickle cell disease
26443252 distribution of HLA-DQB1*0602 was not statistically different among multiple sclerosis patients and controls in Khuzestan Province, Iran
26398634 DQ7 (presence of DQB1*0301/0304 (DRB1*11/12/X) alleles) represents an additive or independent celiac disease risk haplotype.
26362370 Pharmacoresistant temporal lobe epilepsy associated with mesial hippocampal sclerosis is not determined by HLA class II alleles in the DRB1, DQB1, and DQA1 regions but the HLA DRB1*1302 allele exhibited a tendency to behave as a susceptibility factor

AA Sequence


Text Mined References (1362)

PMID Year Title
27049564 2016 Increased occurrence of anti-AQP4 seropositivity and unique HLA Class II associations with neuromyelitis optica (NMO), among Muslim Arabs in Israel.
26829741 2016 [Analysis of the association of human leukocyte antigen DQ gene polymorphisms with unexplained recurrent spontaneous abortion among ethnic Han Chinese from Wenzhou region].
26818121 2016 Association of HLA-DQ alleles with the presence of an anti-?2-glycoprotein I antibody in patients with recurrent miscarriage.
26744784 2015 The association of HLA-DRB1 and HLA-DQB1 alleles with genetic susceptibility to multiple sclerosis in the Slovak population.
26681219 2015 Analysis of HLA-DQB1 allele polymorphisms in Uyghur women with cervical cancer.
26671138 2015 Association of HLA class II (DRB1, DQA1, DQB1) alleles and haplotypes with myasthenia gravis and its subgroups in the Iranian population.
26476208 2016 Protective effect of HLA-DQB1 alleles against alloimmunization in patients with sickle cell disease.
26443252 2015 Analysis of HLA-DQB1*0602 in Multiple Sclerosis Patients in Khuzestan Province, Iran.
26398634 2015 High Frequency of Haplotype HLA-DQ7 in Celiac Disease Patients from South Italy: Retrospective Evaluation of 5,535 Subjects at Risk of Celiac Disease.
26362370 2015 Genetic association study of the HLA class II alleles DRB1, DQA1, and DQB1 in patients with pharmacoresistant temporal lobe epilepsy associated with mesial hippocampal sclerosis.